Evidence supporting the use of: Pomegranate
For the health condition: Cardiovascular Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Pomegranate (Punica granatum) has been traditionally consumed for its health benefits, but in recent decades, scientific research has explored its specific effects on cardiovascular health. The fruit and its juice are rich in polyphenols, particularly punicalagins and anthocyanins, which possess strong antioxidant and anti-inflammatory properties. Multiple clinical studies have investigated the ability of pomegranate juice to reduce blood pressure, improve lipid profiles, and decrease oxidative stress in the vasculature. For example, some randomized controlled trials demonstrate that regular consumption of pomegranate juice (typically 1 cup daily for several weeks or months) can modestly lower systolic and diastolic blood pressure in individuals with hypertension.

Additionally, small human studies suggest pomegranate may improve cholesterol levels by lowering LDL oxidation and possibly increasing HDL cholesterol. Animal studies have provided further evidence of pomegranate’s ability to reduce atherosclerotic plaque formation. The proposed mechanisms include increased nitric oxide availability, reduced inflammation, and inhibition of LDL oxidation. Nevertheless, while the findings are promising, the overall body of evidence is limited by small sample sizes and relatively short study durations. Larger, long-term clinical trials are needed to confirm these effects and establish clear recommendations.

In summary, there is scientific evidence supporting the use of pomegranate for cardiovascular health, but it is not yet conclusive or sufficient for strong clinical recommendations. The evidence quality is moderate, justifying a rating of 3 out of 5.

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Other ingredients used for Cardiovascular Disease

7-hydroxymatairesinol (HMR)
acai berry
acetyl l-carnitine
ajoene
algal oil
alpha-carotene
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
apple
arjun tree
astaxanthin
astragalus
basil
beet
berry flavor
bilberry
black garlic
black tea
blackberry
blueberry
bonito peptide
broccoli
calamari oil
campesterol
canola oil
capsaicinoids
catechins
caterpillar mushroom
chia seed
chokeberry
choline
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
conjugated linoleic acid (CLA)
cryptoxanthin
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ethanol
fiber blend (proprietary)
fisetin
fish oil
fish protein
flavonols
flaxseed
folate
fruit and vegetable blend (proprietary)
gamma tocopherol
garlic bulb
genistein
ginger
ginseng
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
HMR lignan
krill oil
l-arginine
l-carnitine
l-carnosine
l-citrulline
l-glycine
l-taurine
lactobacillus reuteri
lignans
linoleic acid (LA)
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
motherwort
mustard seed
n-acetyl-cysteine (NAC)
nattokinase
nicotinamide riboside
oleic acid
olive
omega-3 fatty acids
omega-6 fatty acids
omega-9 fatty acids
orange
palmitoleic acid
pantethine
phenolic acids
phospholipids
phytosterols
pine bark
pineapple
plant sterols
policosanol
pollen
pomegranate
potassium
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
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red yeast rice
reishi mushroom
resveratrol
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rutin
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selenium
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sitostanol
soybean
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spinach
sterols
strawberry
sulforaphane glucosinolate
tocotrienols
tomato
trans-pterostilbene
trimethylglycine (TMG)
triphala
almond fruit
ubiquinol
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vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
vitamin K
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commiphora
ferulic acid
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polyphenols
trace minerals
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millet seed
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cocoa
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5-methyltetrahydrofolate glucosamine
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Ardisia
Apigenin
Aronia melanocarpa
Allicin
Antirrhinin
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Adrenergic amines
Acacetin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Asteracea
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anthocyanosides
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Apocynin
Arginine silicate
Arjunolic acid
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Butylphthalide
Bidens pilosa
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Brutieridin
Brassica
Bishop's Weed
Benfotiamine
Basidiomycota
Betanin
berry
Brazil nut
boysenberry
Bioflavonoids
Bee products
banana
Baicalin
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Caffeic Acid
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epicatechin
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Ellagitannin
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Flavonoids
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