Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a flavonoid found in many fruits and vegetables, and has been the subject of research for its potential cardiovascular benefits. Scientific interest in quercetin's use for cardiovascular disease (CVD) is based on its antioxidant, anti-inflammatory, and vasodilatory properties. Several in vitro and animal studies suggest that quercetin can reduce oxidative stress and inflammation, both of which are implicated in the pathogenesis of atherosclerosis and hypertension. Human studies have shown mixed results, but some randomized controlled trials indicate that quercetin supplementation may modestly lower blood pressure and improve endothelial function in individuals with hypertension or at risk for CVD. For example, a 2016 meta-analysis (Serban et al., Nutrition Reviews) found that quercetin supplementation was associated with a statistically significant reduction in systolic and diastolic blood pressure. However, the overall quality and quantity of evidence in humans is limited, with most studies being small, short-term, or using varying doses and formulations of quercetin. There is insufficient evidence to conclude that quercetin alone prevents or treats cardiovascular disease, and no major cardiovascular society currently recommends it for this purpose. Thus, while there is a scientific rationale and preliminary clinical data suggesting some benefit, the evidence base is not strong, and quercetin should not be considered a substitute for established therapies.

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