Evidence supporting the use of: Resveratrol
For the health condition: Cardiovascular Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol is a polyphenolic compound found in grapes, red wine, berries, and some other plants. Its use for cardiovascular disease (CVD) is supported by mechanistic and preclinical data, as well as some small clinical trials, but large-scale clinical evidence in humans remains limited.

Resveratrol has been shown in laboratory and animal studies to possess antioxidant, anti-inflammatory, and vasodilatory properties. These activities may help protect the endothelium (the inner lining of blood vessels), reduce LDL cholesterol oxidation, inhibit platelet aggregation, and improve lipid profiles—all factors relevant to cardiovascular health. Epidemiological observations, such as the "French Paradox" (lower rates of coronary heart disease despite high dietary saturated fat intake, possibly linked to red wine consumption), have also spurred interest in resveratrol's potential role.

Small human studies suggest that resveratrol supplementation may improve some markers of cardiovascular health, such as endothelial function and inflammation. However, most clinical trials have been short-term, used varying doses, and involved small numbers of participants. Meta-analyses indicate only modest benefits on blood pressure, lipid levels, or glycemic control, and long-term safety and efficacy have not been established.

In summary, while there is scientific rationale and limited human evidence for resveratrol’s cardiovascular benefits, the current level of evidence supporting its use in the prevention or treatment of CVD is modest (rated 2/5). More rigorous, large-scale clinical trials are needed to confirm its effectiveness and establish appropriate dosing.

More about resveratrol
More about Cardiovascular Disease

Other ingredients used for Cardiovascular Disease

7-hydroxymatairesinol (HMR)
acai berry
acetyl l-carnitine
ajoene
algal oil
alpha-carotene
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
apple
arjun tree
astaxanthin
astragalus
basil
beet
berry flavor
bilberry
black garlic
black tea
blackberry
blueberry
bonito peptide
broccoli
calamari oil
campesterol
canola oil
capsaicinoids
catechins
caterpillar mushroom
chia seed
chokeberry
choline
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
conjugated linoleic acid (CLA)
cryptoxanthin
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ethanol
fiber blend (proprietary)
fisetin
fish oil
fish protein
flavonols
flaxseed
folate
fruit and vegetable blend (proprietary)
gamma tocopherol
garlic bulb
genistein
ginger
ginseng
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
HMR lignan
krill oil
l-arginine
l-carnitine
l-carnosine
l-citrulline
l-glycine
l-taurine
lactobacillus reuteri
lignans
linoleic acid (LA)
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
motherwort
mustard seed
n-acetyl-cysteine (NAC)
nattokinase
nicotinamide riboside
oleic acid
olive
omega-3 fatty acids
omega-6 fatty acids
omega-9 fatty acids
orange
palmitoleic acid
pantethine
phenolic acids
phospholipids
phytosterols
pine bark
pineapple
plant sterols
policosanol
pollen
pomegranate
potassium
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
raspberry
red yeast rice
reishi mushroom
resveratrol
rhizome
rutin
sardines
secoisolariciresinol diglucoside
selenium
black ginger
sitostanol
soybean
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spinach
sterols
strawberry
sulforaphane glucosinolate
tocotrienols
tomato
trans-pterostilbene
trimethylglycine (TMG)
triphala
almond fruit
ubiquinol
Urolithin A
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
vitamin K
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
red clover
jiaogulan
gastrodia
capsicum
commiphora
ferulic acid
chrysanthemum
cistanche
ganoderma
royal jelly
polyphenols
trace minerals
yerba mate
goji berry
amaranth
millet seed
herbal blend (proprietary)
algae
cocoa
AMP-activated protein kinase (AMPK)
cayenne pepper
soy isoflavones
15,16-Dihydrotanshinone I
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
5-methyltetrahydrofolate glucosamine
Alcohol
Arjuna
Animal Tissue
Arginine Creatine
Arginine nitrate
Ardisia
Apigenin
Aronia melanocarpa
Allicin
Antirrhinin
Avocado
Adrenergic amines
Acacetin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Asteracea
Alpha phytosterol
Acetylsalicylic acid
Algal protein
Acer Truncatum bunge
Arjunic Acid
Alliin
anthocyanosides
Argan nut oil
Apocynin
Arginine silicate
Arjunolic acid
Astragalin
Black Seed
Butylphthalide
Bidens pilosa
Beta-hydroxybutyrate
Brutieridin
Brassica
Bishop's Weed
Benfotiamine
Basidiomycota
Betanin
berry
Brazil nut
boysenberry
Bioflavonoids
Bee products
banana
Baicalin
Bassia scoparia
Chia seed
Caffeic Acid
Camellia sinensis
Carnosine
Calycosin
Camelina Oil
Cashew
Cyanidin
Citrus
Capsaicin
Catecholamine
Cowherb
Cruciferous
Curcumen
Chocolate
Curcuma
Calanus finmarchicus
C-Phycocyanin
Coumaric acid
Crocetin
Currant
Docosahexaenoic Acid
Diallyl sulfide
Danshen
Delphinidin
Date
Digitalis
Diosmetin
epicatechin
E-Viniferin
Ellagic Acid
Eriocitrin
Eupolyphaga sinensis
Ergothioneine
Emblicanin
Eicosatetraenoic acid
Erythrodiol
Eicosapentaenoic Acid
Eucommia ulmoides
Ellagitannin
Folic Acid
Fiber
Flavonoids
Flavonones
Garlic
Glycine
Isoflavones
peanut
Pistachio
Soy Protein
walnut
Zucchini

Products containing resveratrol

Vitabase Active Woman's Multi
Thorne Advanced Nutrients Multivitamin
Designs For Health ArthroSoothe™
Designs For Health ArthroSoothe™ Supreme
Pure Encapsulations Balanced Immune
Designs For Health BioFizz® Immune
Designs For Health CellGuard-NR 60 Capsules
Designs For Health FemGuard+Balance™
Designs For Health Inflammatone™
Designs For Health Inflammatone™
Klean Athlete Klean Multivitamin ™
Thorne L-Arginine Plus Perfusia Plus
Pure Encapsulations Memory Pro
Pure Encapsulations Memory Pro
Pure Encapsulations Metabolic Xtra
Douglas Laboratories Methlyated Resveratrol Plus
Pure Encapsulations Mitochondria-ATP
Designs For Health Mitochondrial NRG™
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Thorne PolyResveratrol-SR
Designs For Health Primal Multi™
Pure Encapsulations Renual
Pure Encapsulations ResCu-SR®
Thorne ResveraCel
Pure Encapsulations Resveratrol
Pure Encapsulations Resveratrol
Douglas Laboratories Resveratrol
Pure Encapsulations Resveratrol Extra
Pure Encapsulations Resveratrol Extra
Designs For Health Resveratrol Supreme
Integrative Therapeutics Resveratrol Ultra HP 175mg
Pure Encapsulations Resveratrol VESIsorb®
Pure Encapsulations RevitalAge™ Ultra
Designs For Health Ultimate Antiox Full Spectrum
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Pure Encapsulations Ultra Pure Pack
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Vitabase Women's Support