Relationship: Cardiovascular Disease and vitamin C

Evidence supporting the use of: Vitamin C
For the health condition: Cardiovascular Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C (ascorbic acid) has been investigated for its potential role in supporting cardiovascular health due to its antioxidant properties, effects on endothelial function, and influence on blood pressure. Epidemiological studies have suggested that higher dietary intake of vitamin C is associated with a reduced risk of cardiovascular disease (CVD). Mechanistically, vitamin C may help protect low-density lipoprotein (LDL) cholesterol from oxidation, improve nitric oxide production (leading to vasodilation), and reduce systemic inflammation—all factors relevant to the pathogenesis of CVD.

However, randomized controlled trials (RCTs) and meta-analyses of vitamin C supplementation have generally shown modest or no significant benefit in preventing major cardiovascular events or reducing mortality. Some RCTs have reported small reductions in blood pressure and improvements in endothelial function, especially in people with low baseline vitamin C levels or those with established hypertension. The effects on lipid profiles and atherosclerotic outcomes are inconsistent. Major guidelines do not recommend vitamin C supplementation specifically for prevention or treatment of CVD in the general population, emphasizing lifestyle and pharmacologic interventions with stronger evidence.

In summary, while there is a plausible scientific rationale and some observational data, high-quality clinical evidence supporting vitamin C supplementation for cardiovascular disease is limited. Its use is better justified for individuals with deficiency, but not as a general preventive or therapeutic strategy for CVD.

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Other ingredients used for Cardiovascular Disease

15,16-Dihydrotanshinone I
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
5-methyltetrahydrofolate glucosamine
7-hydroxymatairesinol (HMR)
Acacetin
Acai berry
Acer truncatum
Acetyl L-carnitine
Adrenergic amines
Ajoene
Alcohol
Algae
algal oil
Algal protein
Allicin
Alliin
Almond fruit
Alpha phytosterol
Alpha-carotene
alpha-linolenic acid (ALA)
alpha-lipoic acid
amaranth
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
animal Tissue
anthocyanidins
anthocyanins
anthocyanosides
antirrhinin
apigenin
apocynin
apple
Ardisia
argan nut oil
arginine creatine
Arginine nitrate
Arginine silicate
arjun tree
arjuna
arjunic acid
Arjunolic acid
Aronia melanocarpa
astaxanthin
Asteraceae
astragalin
astragaloside
astragalus
avocado
baicalin
banana
Basidiomycota
basil
Bassia scoparia
bee products
beet
benfotiamine
berry
beta-hydroxybutyrate
betanin
Bidens pilosa
bilberry
bioflavonoids
bishop\'s weed
black garlic
black ginger
black seed
black tea
blackberry
blueberry
bonito peptide
boysenberry
Brassica
Brazil nut
broccoli
brutieridin
butylphthalide
C-phycocyanin
caffeic Acid
calamari oil
Calanus finmarchicus
calycosin
camelina oil
Camellia sinensis
campesterol
capsaicin
capsaicinoids
capsicum
Carnosine
cashew
catechins
catecholamine
caterpillar mushroom
cayenne pepper
chia seed
chia seed
chocolate
chokeberry
choline
chrysanthemum
cinnamon
cistanche
Citrus
citrus bioflavonoids
citrus sinensis (proprietary)
cocoa
coenzyme Q10 (CoQ10)
commiphora
conjugated linoleic acid (CLA)
coumaric acid
cowherb
crocetin
cruciferous
cryptoxanthin
Curcuma
curcumen
curcumin
currant
cyanidin
d-alpha tocopherol
danshen
date
delphinidin
DHA (docosahexaenoic acid)
diallyl sulfide
Digitalis
diosmetin
docosahexaenoic Acid
DPA (docosapentaenoic acid)
E-Viniferin
eicosapentaenoic acid
Eicosatetraenoic acid
ellagic acid
ellagitannin
emblicanin
EPA (eicosapentaenoic acid)
epicatechin
epigallocatechin gallate (EGCG)
ergothioneine
eriocitrin
erythrodiol
Eucommia ulmoides
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fatty acids
ferulic acid
fiber
fiber blend (proprietary)
fisetin
fish
fish oil
fish protein
flavanols
flavanones
flavans
flavones
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flavonones
flaxseed
folate
folic acid
formononetin
foxglove
fruit
fruit and vegetable blend (proprietary)
fungus
gamma tocopherol
ganoderma
garlic
garlic bulb
gastrodia
genistein
ginger
ginseng
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goji berry
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green tea
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hydroxycinnamic acid
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hydroxytyrosol
Hyperoside
icariin
Ilex
inositol nicotinate
isoflavones
isoliquiritigenin
isoquinoline alkaloids
isothiocyanates
jiaogulan
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Kokilaksha
krill oil
L-arginine
l-carnitine
L-carnosine
L-citrulline
L-glycine
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Lactobacillus reuteri
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lignans
Ligusticum
ligustilides
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linoleic acid (LA)
lipids
lumbrokinase
luteolin
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lycopene
macadamia
magnesium
malvidin
mangiferin
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Mate
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millet seed
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Momordica
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mustard seed
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nicotinamide riboside
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oleic acid
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pineapple
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proanthocyanidins
procyanidin
procyanidol
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Propolis
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punicalagins
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pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
pyrroloquinoline quinone
quercetin
rapeseed oil
raspberry
red clover
red yeast
red yeast rice
reishi mushroom
resveratrol
rhizome
ribose
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Rooibos
royal jelly
Rutaecarpine
rutin
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sitostanol
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soybean
specialized pro-resolving mediators (SPMs)
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spinach
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ubiquinol
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vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
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vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
vitamin K
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White Tea
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Xanthophyll
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Zingiberene
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β-nicotinamide mononucleotide (NMN)

Other health conditions supported by vitamin C

Abrasions
Abscesses
Acne
Acquired Immune Deficiency Syndrome
Addictions (general remedies for)
Addison's Disease
Adrenal Fatigue
Age Spots
Aging (prevention)
Alcoholism
Allergies (food)
Allergies (respiratory)
Alzheimer's Disease
Anal Fistula or Fissure
Anemia
Antibiotics (alternatives to)
Antibiotics (side effects of)
Anxiety
Arteriosclerosis
Arthritis
Asthma
Athletic and Exercise Aids
Autism
Autoimmune Disorders
Bell's Palsy
Bites and Stings
Bladder Infection
Bleeding (external)
Bleeding (internal)
Blood Poisoning
Boils
Bronchitis
Bruises (healing)
Bruises (prevention)
Burns and Scalds
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Canker Sores
Capillary Weakness
Carbuncles
Cardiovascular Disease
Cartilage Damage
Cataracts
Cervical Dysplasia
Chemical Poisoning
Chemotherapy (reducing side effects)
Chicken Pox
Cholesterol (high)
Chronic Obstructive Pulmonary Disorder
Cold Sores
Colds (antiviral)
Colds (decongestant)
Colds (general)
Colds (prevention)
Colds (with fever)
Colon (atonic)
Congestion
Congestion (bronchial)
Congestion (lungs)
Congestion (sinus)
Conjunctivitis
Contagious Diseases
Convalescence
Copper Toxicity
Cough (dry)
Cough (general)
Cuts
Cystic Breast Disease
Cystic Fibrosis
Debility
Dementia
Denture Sores
Depression
Diabetes
Diabetic Retinopathy
Environmental Pollution
Epstein Barr Virus
Eye Problems
Eyesight (poor)
Fatigue
Fatty Liver Disease
Free Radical Damage
Gall Stones
Gastritis
Gingivitis
Glaucoma
Gonorrhea
Gout
Hair (loss or thinning)
Hair Care (general)
Heart (weakness)
Heavy Metal Poisoning
Hemorrhoids
Hepatitis
Herpes
Hot Flashes
Hypertension
Infection
Infection (bacterial)
Infection (viral)
Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Knees (weak)
Laryngitis
Lead Poisoning
Lesions
Leucorrhea
Leukemia
Ligaments (torn or injured)
Liver Detoxification
Lyme Disease
Macular Degeneration
Mastitis
Measles
Memory and Brain Function
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Metabolic Syndrome
Mononucleosis
Mumps
Nose Bleeds
Oral Surgery
Osteoporosis
Pancreatitis
PMS (general)
PMS Type C
PMS Type H
Pneumonia
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Prolapsed Uterus
Prostatitis
Radiation Sickness
Rashes and Hives
Restless Leg Syndrome
Rheumatoid Arthritis
Rhinitis
Rhinitis, Allergic
Rosacea
Scars / Scar Tissue
Schizophrenia
Scratches and Abrasions
Scurvy
Shingles
Shock
Sinus Infection
Skin (infections)
Skin Care (general)
Sore Throat
Spider Veins
Spinal Disks
Sprains
Strep Throat
Stretch Marks
Sunburn
Surgery (healing from)
Surgery (preparation for)
Teeth (loose)
Tendonitis
Thrush
Tickle in Throat
Tonsillitis
Tooth Extraction
Toxemia
Triglycerides (high)
Tuberculosis
Ulcerations (external)
Ulcers
Uric Acid Retention
Urinary Tract Infections
Vaginitis
Varicose Veins
Warts
Wounds and Sores
Wrinkles

Products containing vitamin C

Health Concerns

Brands

Evidence supporting the use of: Vitamin C
For the health condition: Cardiovascular Disease

Table of Contents

Synopsis

Other ingredients used for Cardiovascular Disease

Other health conditions supported by vitamin C

Products containing vitamin C

Health Concerns

Brands

Evidence supporting the use of: Vitamin CFor the health condition: Cardiovascular Disease

Table of Contents

Synopsis

Other ingredients used for Cardiovascular Disease

Other health conditions supported by vitamin C

Products containing vitamin C

Evidence supporting the use of: Vitamin C
For the health condition: Cardiovascular Disease