Relationship: Cardiovascular Disease and vitamin C

Evidence supporting the use of: Vitamin C
For the health condition: Cardiovascular Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C (ascorbic acid) has been investigated for its potential role in supporting cardiovascular health due to its antioxidant properties, effects on endothelial function, and influence on blood pressure. Epidemiological studies have suggested that higher dietary intake of vitamin C is associated with a reduced risk of cardiovascular disease (CVD). Mechanistically, vitamin C may help protect low-density lipoprotein (LDL) cholesterol from oxidation, improve nitric oxide production (leading to vasodilation), and reduce systemic inflammation—all factors relevant to the pathogenesis of CVD.

However, randomized controlled trials (RCTs) and meta-analyses of vitamin C supplementation have generally shown modest or no significant benefit in preventing major cardiovascular events or reducing mortality. Some RCTs have reported small reductions in blood pressure and improvements in endothelial function, especially in people with low baseline vitamin C levels or those with established hypertension. The effects on lipid profiles and atherosclerotic outcomes are inconsistent. Major guidelines do not recommend vitamin C supplementation specifically for prevention or treatment of CVD in the general population, emphasizing lifestyle and pharmacologic interventions with stronger evidence.

In summary, while there is a plausible scientific rationale and some observational data, high-quality clinical evidence supporting vitamin C supplementation for cardiovascular disease is limited. Its use is better justified for individuals with deficiency, but not as a general preventive or therapeutic strategy for CVD.

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Other ingredients used for Cardiovascular Disease

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Acai berry
Acetyl L-carnitine
Ajoene
algal oil
Alpha-carotene
alpha-linolenic acid (ALA)
amino acids
anchovies
anthocyanins
apple
arjun tree
astaxanthin
astragalus
basil
beet
berry flavor
bilberry
black garlic
black tea
blackberry
blueberry
bonito peptide
broccoli
calamari oil
campesterol
canola oil
capsaicinoids
catechins
caterpillar mushroom
chia seed
chokeberry
choline
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
coenzyme Q10 (CoQ10)
conjugated linoleic acid (CLA)
cryptoxanthin
curcumin
d-alpha tocopherol
DHA (docosahexaenoic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ethanol
fiber blend (proprietary)
fisetin
fish oil
fish protein
flavonols
flaxseed
folate
fruit and vegetable blend (proprietary)
gamma tocopherol
garlic bulb
genistein
ginger
ginseng
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
HMR lignan
krill oil
L-arginine
l-carnitine
L-carnosine
L-citrulline
L-glycine
L-taurine
Lactobacillus reuteri
lignans
linoleic acid (LA)
luteolin
lycopene
magnesium
Marine lipid
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Motherwort
mustard seed
N-acetyl-cysteine (NAC)
Nattokinase
nicotinamide riboside
oleic acid
olive
omega-3 fatty acids
omega-6 fatty acids
omega-9 fatty acids
orange
palmitoleic acid
pantethine
phenolic compounds
phospholipids
phytosterols
pine bark
pineapple
plant sterols
policosanol
pollen
pomegranate
potassium
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline disodium salt
quercetin
raspberry
red yeast rice
reishi mushroom
resveratrol
rhizome
rutin
secoisolariciresinol diglucoside
selenium
black ginger
sitostanol
soybean
specialized pro-resolving mediators (SPMs)
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sterols
strawberry
sulforaphane glucosinolate
tocotrienols
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ubiquinol
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vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
vitamin K
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red clover
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arjuna
animal Tissue
arginine creatine
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apigenin
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antirrhinin
avocado
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Acacetin
alpha-lipoic acid
astragaloside
anthocyanidins
ampelopsin
Asteraceae
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arjunic acid
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anthocyanosides
argan nut oil
apocynin
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astragalin
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brutieridin
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benfotiamine
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boysenberry
bioflavonoids
bee products
banana
baicalin
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caffeic Acid
Camellia sinensis
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calycosin
camelina oil
cashew
cyanidin
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capsaicin
catecholamine
cowherb
cruciferous
curcumen
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folic acid
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fiber
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formononetin
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fatty acids
fungus
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flavans
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garlic
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Higenamine
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hydroxycinnamic acid
hazelnut
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inositol nicotinate
isoliquiritigenin
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isoquinoline alkaloids
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macadamia
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vegetable oil
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Other health conditions supported by vitamin C

Abrasions
Abscesses
Acne
Acquired Immune Deficiency Syndrome
Addictions (general remedies for)
Addison's Disease
Adrenal Fatigue
Age Spots
Aging (prevention)
Alcoholism
Allergies (food)
Allergies (respiratory)
Alzheimer's Disease
Anal Fistula or Fissure
Anemia
Antibiotics (alternatives to)
Antibiotics (side effects of)
Anxiety
Arteriosclerosis
Arthritis
Asthma
Athletic and Exercise Aids
Autism
Autoimmune Disorders
Bell's Palsy
Bites and Stings
Bladder Infection
Bleeding (external)
Bleeding (internal)
Blood Poisoning
Boils
Bronchitis
Bruises (healing)
Bruises (prevention)
Burns and Scalds
Cancer (natural therapy for)
Cancer (prevention)
Cancer Treatment (reducing side effects)
Canker Sores
Capillary Weakness
Carbuncles
Cardiovascular Disease
Cartilage Damage
Cataracts
Cervical Dysplasia
Chemical Poisoning
Chemotherapy (reducing side effects)
Chicken Pox
Cholesterol (high)
Chronic Obstructive Pulmonary Disorder
Cold Sores
Colds (antiviral)
Colds (decongestant)
Colds (general)
Colds (prevention)
Colds (with fever)
Colon (atonic)
Congestion
Congestion (bronchial)
Congestion (lungs)
Congestion (sinus)
Conjunctivitis
Contagious Diseases
Convalescence
Copper Toxicity
Cough (dry)
Cough (general)
Cuts
Cystic Breast Disease
Cystic Fibrosis
Debility
Dementia
Denture Sores
Depression
Diabetes
Diabetic Retinopathy
Environmental Pollution
Epstein Barr Virus
Eye Problems
Eyesight (poor)
Fatigue
Fatty Liver Disease
Free Radical Damage
Gall Stones
Gastritis
Gingivitis
Glaucoma
Gonorrhea
Gout
Hair (loss or thinning)
Hair Care (general)
Heart (weakness)
Heavy Metal Poisoning
Hemorrhoids
Hepatitis
Herpes
Hot Flashes
Hypertension
Infection
Infection (bacterial)
Infection (viral)
Infertility
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Knees (weak)
Laryngitis
Lead Poisoning
Lesions
Leucorrhea
Leukemia
Ligaments (torn or injured)
Liver Detoxification
Lyme Disease
Macular Degeneration
Mastitis
Measles
Memory and Brain Function
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Metabolic Syndrome
Mononucleosis
Mumps
Nose Bleeds
Oral Surgery
Osteoporosis
Pancreatitis
PMS (general)
PMS Type C
PMS Type H
Pneumonia
Post Partum Weakness
Pregnancy (herbs and supplements for)
Progesterone (low)
Prolapsed Uterus
Prostatitis
Radiation Sickness
Rashes and Hives
Restless Leg Syndrome
Rheumatoid Arthritis
Rhinitis
Rhinitis, Allergic
Rosacea
Scars / Scar Tissue
Schizophrenia
Scratches and Abrasions
Scurvy
Shingles
Shock
Sinus Infection
Skin (infections)
Skin Care (general)
Sore Throat
Spider Veins
Spinal Disks
Sprains
Strep Throat
Stretch Marks
Sunburn
Surgery (healing from)
Surgery (preparation for)
Teeth (loose)
Tendonitis
Thrush
Tickle in Throat
Tonsillitis
Tooth Extraction
Toxemia
Triglycerides (high)
Tuberculosis
Ulcerations (external)
Ulcers
Uric Acid Retention
Urinary Tract Infections
Vaginitis
Varicose Veins
Warts
Wounds and Sores
Wrinkles

Products containing vitamin C

Health Concerns

Brands

Evidence supporting the use of: Vitamin C
For the health condition: Cardiovascular Disease

Table of Contents

Synopsis

Other ingredients used for Cardiovascular Disease

Other health conditions supported by vitamin C

Products containing vitamin C

Health Concerns

Brands

Evidence supporting the use of: Vitamin CFor the health condition: Cardiovascular Disease

Table of Contents

Synopsis

Other ingredients used for Cardiovascular Disease

Other health conditions supported by vitamin C

Products containing vitamin C

Evidence supporting the use of: Vitamin C
For the health condition: Cardiovascular Disease