Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E has been investigated for its potential role in supporting or treating cardiovascular disease (CVD) due to its antioxidant properties, which could theoretically prevent the oxidative modification of low-density lipoprotein (LDL) cholesterol—a process believed to contribute to atherosclerosis. Early observational studies suggested an association between higher vitamin E intake and reduced risk of heart disease, prompting widespread use of vitamin E supplements for cardiovascular health, especially in the 1990s.

However, large randomized controlled trials (RCTs) and meta-analyses have generally failed to demonstrate a significant benefit of vitamin E supplementation in reducing the incidence of major cardiovascular events, such as myocardial infarction, stroke, or cardiovascular mortality. Notably, the HOPE and GISSI-Prevenzione trials, among others, showed no substantial protective effect of vitamin E supplementation in patients at high risk for or with existing CVD. Some studies have even suggested a potential for harm, such as increased risk of hemorrhagic stroke with high-dose supplementation.

Despite these findings, vitamin E continues to be used by some individuals for heart health, largely due to earlier enthusiasm and its theoretical antioxidant benefit. Current clinical guidelines do not recommend vitamin E supplementation for the prevention or treatment of cardiovascular disease in the general population. Thus, while the use of vitamin E for CVD is grounded in scientific rationale, robust clinical evidence does not support its efficacy for this purpose.

More about vitamin E
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Other ingredients used for Cardiovascular Disease

Other health conditions supported by vitamin E

Products containing vitamin E

Designs For Health Acnutrol™ capsules
Vitabase Active Man's Formula
Vitabase Active Woman's Multi
Designs For Health ADK-Evail™
Metagenics AdvaClear
Metagenics AdvaClear
Thorne Advanced Nutrients Multivitamin
Designs For Health Annatto-E® 300
Designs For Health Annatto-E® 150
Designs For Health Annatto-E® 150
Designs For Health Annatto-E® Synergy (formerly Annatto Tocotrienols)
Designs For Health Annatto-E/GG
Pure Encapsulations AntiOxidant Formula
Metagenics Axis Endo™ Mango
Thorne Basic Nutrients 2/Day Multivitamin
Thorne Basic Prenatal Multivitamin
Designs For Health BioFizz® Immune
Pure Encapsulations Black Currant Seed
Pure Encapsulations Black Currant Seed
Vitabase Blood Sugar Formula
Pure Encapsulations Borage Oil 1,000 mg
Pure Encapsulations Borage Oil 1,000 mg
Metagenics CardioLux® HDL
Pure Encapsulations CLA 1000 mg
Pure Encapsulations CLA 1000 mg
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change Daily Essentials
Integrative Therapeutics Clinical Nutrients HP
Douglas Laboratories Co-Enzyme Q10 Softgel
Metagenics CoQ10 ST®-100 mg
Metagenics CoQ10 ST-100 mg
Metagenics CoQ10 ST-200 mg
Designs For Health Detox Antiox™
Integrative Therapeutics Detoxication Factors
Integrative Therapeutics Detoxication Factors
Designs For Health Detoxification Support Packets
Designs For Health DFH Complete Multi™
Designs For Health DFH Complete Multi™ with Copper
Designs For Health DFH Complete Multi™ with Copper & Iron
Pure Encapsulations DIM-PRO® 100
Pure Encapsulations DIM-PRO® 100
Douglas Laboratories E-400
Metagenics E-400 Selenium™
Metagenics E Complex 1:1™
Metagenics Endura® Lemonade
Pure Encapsulations Energize Plus™ Pure Pack
Pure Encapsulations EPA Ultimate
Metagenics EstroFactors®
Pure Encapsulations EyeProtect Basics
Pure Encapsulations EyeProtect Basics without Zinc
Metagenics Fem EstroPlex®
Metagenics Fem Prenatal®
Designs For Health FemGuard-HF™
Metagenics GI Sustain™ Powder
Vitabase Hair, Skin & Nails Formula
Designs For Health Hi-Po Emulsi-D3™
Integrative Therapeutics K-PAX MitoNutrients
Metagenics Ketogenic Shake Chocolate
Metagenics Ketogenic Shake Vanilla
Klean Athlete Klean Multivitamin ™
Vitabase Life's Essentials Plus
Pure Encapsulations Liposomal Glutathione
Designs For Health Lipotrienols RYR™
Douglas Laboratories Liquid Multivitamin
Pure Encapsulations LiquiNutrients
Douglas Laboratories Lutein
Thorne MediClear Plus
Thorne Men's Multi 50+
Designs For Health Metabolic Synergy™
Designs For Health Metabolic Synergy™
Metagenics MetaGlycemX™
Metagenics MetaGlycemX
Metagenics MetaKids Multi Soft Chew Grape
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Pure Encapsulations Mitochondria-ATP
Pure Encapsulations Multi t/d
Pure Encapsulations Multi t/d
Thorne Multi-Vitamin Elite NSF
Thorne Multi-Vitamin Elite NSF
Metagenics Multigenics®
Metagenics Multigenics Chewable Orange
Metagenics Multigenics Intensive Care
Metagenics Multigenics Intensive Care without Iron
Metagenics Multigenics without Iron
Integrative Therapeutics Multiplex-1 No-Iron
Douglas Laboratories Natural Vitamin E Complex
Pure Encapsulations NeuroMood Pure Pack
Douglas Laboratories Nutri-E 400 ™ Forte
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950® A without Copper & Iron
Pure Encapsulations Nutrient 950® with NAC
Pure Encapsulations Nutrient 950® with Vitamin K
Pure Encapsulations Nutrient 950® without Copper, Iron & Iodine
Pure Encapsulations Nutrient 950® without Iron
Pure Encapsulations Nutrient 950® without Iron
Integrative Therapeutics Nutrivitamin No-Iron
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Designs For Health OcuForce™
Designs For Health OcuForce™ Blue 60 Capsules
Metagenics OmegaGenics GLA 240 mg
Designs For Health OsteoForce™
Designs For Health OsteoForce™
Designs For Health OsteoForce™ Supreme
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™ Detox Program
Designs For Health PaleoCleanse Plus™Chocolate Detox Kit
Designs For Health PaleoMeal®
Designs For Health PaleoMeal®
Vitabase Perfect E
Integrative Therapeutics Physicians Elemental Diet Dextrose Free
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physicians Elemental Diet Kit
Designs For Health PhytoBiome™
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Designs For Health Plant Protein Cleanse
Designs For Health Plant Protein Cleanse Plus™ 570g
Designs For Health Plant Protein Meal
Designs For Health Plant Protein Meal Plus
Designs For Health Plant Protein Meal
Metagenics PlusOne® Daily Prenatal Packs
Pure Encapsulations Polyphenol Nutrients
Pure Encapsulations Polyphenol Nutrients
Douglas Laboratories Prenatal
Pure Encapsulations PreNatal Nutrients
Pure Encapsulations PreNatal Nutrients
Designs For Health Prenatal Pro™
Designs For Health Primal Multi™
Vitabase Prostate Complex (Formerly Prostate Complete)
Pure Encapsulations PureGenomics® Multivitamin
Pure Encapsulations PureGenomics® UltraMultivitamin
Pure Encapsulations PureLean® Protein
Pure Encapsulations PurePals
Pure Encapsulations PurePals with Iron
Pure Encapsulations PureResponse™ Multivitamin
Pure Encapsulations Q-Gel® (Hydrosoluble™ CoQ10) 100 mg
Pure Encapsulations Saw Palmetto Plus with Nettle Root
Pure Encapsulations Saw Palmetto Plus with Nettle Root
Pure Encapsulations Saw Palmetto Plus with Nettle Root
Douglas Laboratories Selenium Plus
Douglas Laboratories Selenium+Vit E
Vitabase Super Antioxidant Formula
Thorne Thyrocsin
Metagenics Thyrosol
Designs For Health Twice Daily Essential Packets
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Douglas Laboratories Ubiquinol-QH
Douglas Laboratories Ubiquinol-QH
Pure Encapsulations Ubiquinol VESIsorb®
Designs For Health Ultimate Antiox Full Spectrum
Thorne Ultimate-E
Douglas Laboratories Ultra G.L.A. Borage Oil
Douglas Laboratories Ultra G.L.A. Borage Oil
Metagenics Ultra Glucose Control® Chocolate
Metagenics Ultra Glucose Control Chocolate
Metagenics Ultra Glucose Control Vanilla
Metagenics Ultra Glucose Control Vanilla
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ® 2 Daily
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories Ultra Preventive ® Kids Grape Flavor
Douglas Laboratories Ultra Preventive ® Kids Orange Flavor
Douglas Laboratories Ultra Preventive One Daily
Douglas Laboratories Ultra Preventive® X
Douglas Laboratories Ultra Protein Green
Pure Encapsulations Ultra Pure Pack
Metagenics UltraClear Detox Powder
Metagenics UltraClear Plus® Detox Powder
Metagenics UltraClear Plus Detox Powder Berry
Metagenics UltraClear Plus Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Vanilla
Metagenics UltraClear RENEW Detox Powder Berry
Metagenics UltraClear RENEW Detox Powder Chai
Metagenics UltraClear RENEW Detox Powder Vanilla
Pure Encapsulations UltraDetox 10-Day Pure Pack
Metagenics UltraGI Replenish® Chocolate
Metagenics UltraGI Replenish Chocolate
Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla
Metagenics UltraInflamX Plus 360°® Chocolate/Orange
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraMeal Advanced Protein® Dutch Chocolate
Metagenics UltraMeal Advanced Protein French Vanilla
Metagenics UltraMeal Advanced Protein Plain
Metagenics UltraMeal Cardio 360°® Pea/Rice Chocolate
Metagenics UltraMeal Cardio 360° Pea/Rice Vanilla
Metagenics UltraMeal® Daily Support Dutch Chocolate
Metagenics UltraMeal Daily Support Mixed Berry
Metagenics UltraMeal Rice Vanilla
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Douglas Laboratories Uro-Pro ®
Pure Encapsulations VisionPro Nutrients
Integrative Therapeutics Vitamin E 400 iu
Pure Encapsulations Vitamin E with Mixed Tocopherols
Pure Encapsulations Vitamin E with Mixed Tocopherols
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Pure Encapsulations Women's Nutrients
Designs For Health Women's Twice Daily Essential Packets