Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin K, particularly in the forms of vitamin K1 (phylloquinone) and K2 (menaquinone), has been increasingly studied for its role in cardiovascular health. Scientific interest is based on vitamin K's critical function in activating matrix Gla protein (MGP), a potent inhibitor of vascular calcification. Vascular calcification is a risk factor for atherosclerosis and cardiovascular events. Observational studies have found that higher dietary intake of vitamin K2 is associated with a reduced risk of coronary heart disease and lower levels of arterial calcification. Some clinical trials have shown that vitamin K supplementation can slow the progression of vascular calcification, particularly in populations at higher risk, such as those with chronic kidney disease. However, the evidence is not yet definitive. Most studies are observational, and while supportive, they do not establish causality. Randomized controlled trials (RCTs) are limited, and results are somewhat mixed. Some RCTs have demonstrated a reduction in the progression of arterial stiffness or calcification with vitamin K2 supplementation, but others have found no significant effect. There is currently insufficient evidence to recommend vitamin K supplementation as a routine therapy for cardiovascular disease in the general population. Nevertheless, the mechanistic rationale and emerging clinical data continue to drive research in this area. In summary, there is a scientific basis and moderate evidence (rated 3/5) for vitamin K's role in supporting cardiovascular health, primarily through its influence on vascular calcification, but more large-scale RCTs are needed for definitive recommendations.

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Other ingredients used for Cardiovascular Disease

Other health conditions supported by vitamin K

Products containing vitamin K

Vitabase Active Woman's Multi
Designs For Health ADK-Evail™
Thorne Advanced Nutrients Multivitamin
Metagenics Axis Endo™ Mango
Thorne Basic Nutrients 2/Day Multivitamin
Thorne Basic Prenatal Multivitamin
Designs For Health BRF 45™
Pure Encapsulations CAL+ with Ipriflavone
Pure Encapsulations CAL+ with Ipriflavone
Pure Encapsulations Calcium K/D
Vitabase Calcium & Magnesium Citrates
Integrative Therapeutics Clinical Nutrients HP
Designs For Health D Evail™ 10K
Designs For Health D-Evail™ Supreme
Designs For Health DFH Complete Multi™
Designs For Health DFH Complete Multi™ with Copper
Designs For Health DFH Complete Multi™ with Copper & Iron
Designs For Health Emulsi-D3 Synergy™
Pure Encapsulations EmulsiSorb K2D3
Metagenics Fem Prenatal®
Douglas Laboratories K2-D3 with Astaxanthin
Vitabase Life's Essentials Plus
Designs For Health Liposomal D Supreme
Douglas Laboratories Liquid D and K
Designs For Health Metabolic Synergy™
Designs For Health Metabolic Synergy™
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Thorne Multi-Vitamin Elite NSF
Thorne Multi-Vitamin Elite NSF
Pure Encapsulations Nutrient 950® with Vitamin K
Integrative Therapeutics Nutrivitamin No-Iron
Designs For Health OmegAvail™ Ultra with Vitamin D3, K1 and K2
Designs For Health Osteoben®
Designs For Health OsteoForce™
Designs For Health OsteoForce™
Designs For Health OsteoForce™ Supreme
Integrative Therapeutics Osteoprime Forte
Integrative Therapeutics Osteoprime Ultra
Integrative Therapeutics Physicians Elemental Diet Dextrose Free
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physicians Elemental Diet Kit
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Metagenics PlusOne® Daily Prenatal Packs
Douglas Laboratories Prenatal
Pure Encapsulations PreNatal Nutrients
Pure Encapsulations PreNatal Nutrients
Designs For Health Prenatal Pro™
Designs For Health Primal Multi™
Integrative Therapeutics ProThrivers Multivitamin
Pure Encapsulations PureGenomics® Multivitamin
Pure Encapsulations PureGenomics® UltraMultivitamin
Pure Encapsulations PureHeart® K2D
Pure Encapsulations PureLean® Protein
Pure Encapsulations PureResponse™ Multivitamin
Pure Encapsulations Synergy K
Pure Encapsulations Synergy K
Designs For Health Tri-K™
Designs For Health Twice Daily Essential Packets
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories Ultra Preventive® X
Douglas Laboratories Ultra Protein Green
Thorne Vitamin D + K2
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Synergy
Metagenics Vitamin D3 10,000 + K
Metagenics Vitamin D3 5000 + K
Thorne Vitamin K (formerly 3-K Complete)
Thorne Vitamin K2
Douglas Laboratories Vitamin K2
Integrative Therapeutics Vitamin K2+D3
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Pure Encapsulations Women's Nutrients
Designs For Health Women's Twice Daily Essential Packets