Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Pyridoxine (Vitamin B6) has been traditionally used as a supplement in the management of carpal tunnel syndrome (CTS), largely based on early reports and anecdotal evidence rather than robust scientific validation. The initial interest stemmed from studies in the 1970s and 1980s that suggested a possible association between low vitamin B6 levels and symptoms of CTS, as well as some small, uncontrolled trials reporting symptomatic improvement with supplementation. However, subsequent controlled studies have not consistently demonstrated clear benefits of pyridoxine for CTS patients, particularly in those who are not deficient in the vitamin. Major reviews and clinical guidelines generally do not recommend pyridoxine supplementation as a standard treatment for CTS, except potentially in individuals confirmed to have a deficiency. The use of vitamin B6 for CTS persists in some alternative medicine and nutritional circles due to its historical application, but current scientific evidence remains weak, with most randomized controlled trials showing little to no effect compared to placebo. In summary, while pyridoxine’s use in CTS is rooted in tradition and early low-quality studies, there is insufficient scientific evidence to support its routine use for this condition in the absence of deficiency.

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