Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has historically been used as a supplement for carpal tunnel syndrome (CTS), primarily based on traditional and anecdotal evidence rather than robust scientific validation. The idea originated in the mid-20th century, when some practitioners observed that individuals with symptoms of nerve compression, such as those seen in CTS, sometimes had low vitamin B6 levels or responded to supplementation. Early studies from the 1970s and 1980s suggested possible benefit, but these were small, often uncontrolled, and results were inconsistent. Some patients reported symptomatic relief, but subsequent larger and more rigorously controlled studies have not consistently demonstrated a clear therapeutic benefit of vitamin B6 for CTS.

Current clinical guidelines and systematic reviews generally do not recommend vitamin B6 as a primary or adjunctive treatment for CTS due to insufficient evidence of efficacy. However, vitamin B6 supplementation may be considered in cases where deficiency is confirmed, as deficiency itself can contribute to peripheral neuropathy. Mixed formulations (including different forms or combinations with other B vitamins) have no proven superiority. In summary, while the use of vitamin B6 for CTS is rooted in tradition and early clinical practice, scientific support is weak, and current best practices rely on other treatments with stronger evidence.

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