Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Vitamin B6 (pyridoxamine, though more commonly in the form of pyridoxine) has been traditionally used as a supplement for carpal tunnel syndrome (CTS), with its use dating back several decades. The rationale behind this traditional use is based on the role of vitamin B6 in nerve function and metabolism. Several small, early studies and anecdotal reports from the 1970s and 1980s suggested that B6 supplementation could alleviate symptoms of CTS, particularly in cases where individuals might have marginal or subclinical deficiency. However, these studies were often limited by methodological flaws such as small sample sizes, lack of controls, and inconsistent diagnostic criteria for CTS and B6 deficiency.

More recent and better-designed clinical trials have generally failed to confirm a significant benefit of B6 supplementation for CTS in the general population. Systematic reviews and guidelines from authoritative bodies (such as the American Academy of Orthopaedic Surgeons) do not recommend B6 as a standard treatment for carpal tunnel syndrome. Currently, the use of vitamin B6 for CTS persists mainly in alternative and complementary medicine circles, supported more by tradition and anecdote than by robust scientific evidence. There is no clear evidence that supplementation is beneficial unless the patient has a true deficiency of vitamin B6, which is rare.

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