Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Vitamin B6 (pyridoxine) has traditionally been used as a treatment or supportive measure for Carpal Tunnel Syndrome (CTS), especially in the complementary and alternative medicine community. The rationale stems from early reports, primarily from the 1970s and 1980s, suggesting that Vitamin B6 deficiency could play a role in peripheral nerve problems, including CTS. Some small, older clinical studies and case reports indicated that supplementation might alleviate symptoms, possibly due to its role in nerve metabolism and function. However, the evidence supporting this use is weak and inconsistent. Later and more rigorous trials have failed to consistently demonstrate a significant benefit of Vitamin B6 supplementation compared to placebo in people with CTS, especially in those who are not deficient in the vitamin. Major reviews and guidelines, such as those from the American Academy of Orthopaedic Surgeons, do not recommend Vitamin B6 for CTS due to insufficient evidence for efficacy. In summary, while the use of Vitamin B6 is rooted in tradition and historical anecdotal evidence, scientific validation is minimal and current consensus does not endorse its use as a standard treatment for Carpal Tunnel Syndrome.

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