Evidence supporting the use of: Chondroitin Sulfate
For the health condition: Cartilage Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Chondroitin sulfate is a naturally occurring component of cartilage and is widely used as a dietary supplement to support joint health and treat cartilage damage, particularly in osteoarthritis. Scientific evidence for its efficacy comes from multiple randomized controlled trials and meta-analyses, though results have been mixed. Some studies indicate that chondroitin sulfate supplementation may reduce pain, improve joint function, and slow joint space narrowing in people with osteoarthritis. Notable among these are the MOVES and GAIT trials, which found moderate benefits in subsets of patients, particularly when chondroitin is combined with glucosamine. However, other large studies and systematic reviews have found little or no clinically meaningful benefit compared to placebo. Major guidelines, such as those from the Osteoarthritis Research Society International (OARSI) and European League Against Rheumatism (EULAR), recognize chondroitin sulfate as a symptomatic treatment with a favorable safety profile, but generally rate its effectiveness as modest. The variability in trial outcomes may be due to differences in supplement quality, patient populations, and study design. In summary, there is moderate scientific evidence supporting the use of chondroitin sulfate for managing symptoms of cartilage damage in osteoarthritis, but it is not universally effective for all patients. Its use is justified by scientific studies, though the magnitude of its benefit is subject to debate and may be clinically modest.

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Other health conditions supported by Chondroitin Sulfate

Arthritis
Cartilage Damage

Products containing Chondroitin Sulfate

We currently have no products on Vitabase that contain this ingredient.