Evidence supporting the use of: Glucosamine (unspecified)
For the health condition: Cartilage Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glucosamine is a natural compound found in cartilage, and its supplements (often derived from shellfish or produced synthetically) have been widely used to support joint health and treat cartilage damage, particularly in the context of osteoarthritis. The rationale behind its use is based on the idea that glucosamine serves as a building block for glycosaminoglycans, which are key components of cartilage matrix. Over the past few decades, multiple clinical trials have investigated glucosamine—alone or in combination with chondroitin—for efficacy in reducing symptoms and slowing the progression of cartilage damage.

Systematic reviews and meta-analyses, including those by Cochrane and other major organizations, indicate that glucosamine may provide a modest benefit in pain relief and function for some individuals with osteoarthritis, particularly of the knee. However, results are inconsistent, and some large, well-conducted randomized controlled trials have found little to no difference compared to placebo. Evidence for actual cartilage repair or regeneration is weak, and radiographic studies generally do not show a significant protective effect on cartilage structure.

While glucosamine is generally considered safe, authoritative guidelines (such as those from the American College of Rheumatology) do not strongly recommend its use due to limited and conflicting evidence. Its use is rooted primarily in scientific investigation rather than longstanding traditional practice. Overall, there is low to moderate quality scientific evidence supporting its use for symptom management, but limited evidence for structural improvement of cartilage.

More about Glucosamine (unspecified)
More about Cartilage Damage

Other health conditions supported by Glucosamine (unspecified)

Arthritis
Cartilage Damage

Products containing Glucosamine (unspecified)

We currently have no products on Vitabase that contain this ingredient.