Evidence supporting the use of: Hydrolyzed gelatin
For the health condition: Cartilage Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hydrolyzed gelatin, also known as collagen hydrolysate, has been investigated for its potential to support cartilage health and treat cartilage damage, such as that seen in osteoarthritis. The rationale is based on the high content of amino acids (notably glycine and proline) that are important for the synthesis of collagen, a major structural component of cartilage. Several small clinical trials have assessed oral collagen supplements, including hydrolyzed gelatin, in individuals with joint pain or cartilage degeneration. Some studies report modest improvements in joint pain and function, with a few indicating potential increases in cartilage matrix synthesis. However, the magnitude of benefit is generally small, and systematic reviews and meta-analyses conclude that the evidence quality is low to moderate, due to issues such as small sample sizes, short duration, and potential bias.

Major health organizations, such as the American College of Rheumatology, do not recommend hydrolyzed gelatin as a primary therapy for cartilage damage, citing insufficient high-quality evidence. Nevertheless, the use of hydrolyzed gelatin is common in dietary supplements marketed for joint health, and there is some biological plausibility for its supportive role. The overall scientific evidence does not strongly validate its use, but it is not completely lacking, warranting a moderate-low evidence rating.

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