Evidence supporting the use of: Hydroxyproline
For the health condition: Cartilage Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hydroxyproline is an amino acid found abundantly in collagen, which is a critical structural protein in cartilage. Its use in supporting or treating cartilage damage is based on the rationale that providing collagen-derived peptides or amino acids may support cartilage repair or slow degeneration. Scientific validation for hydroxyproline’s efficacy comes primarily from studies on collagen hydrolysates, which naturally contain hydroxyproline, rather than isolated hydroxyproline supplementation itself. Some clinical trials and animal studies have shown that collagen hydrolysate supplementation can increase collagen synthesis in cartilage and may help reduce symptoms of osteoarthritis or improve joint health. However, the evidence is modest and sometimes inconsistent, with meta-analyses of randomized controlled trials suggesting only small benefits, if any, for cartilage repair or joint pain. While hydroxyproline is a marker of collagen metabolism and is necessary for collagen stability, there is limited direct evidence that supplemental hydroxyproline alone (as opposed to intact collagen peptides or hydrolysates) has a therapeutic effect on cartilage damage in humans. Most benefits observed are attributed to a combination of amino acids and peptides in collagen supplements, not hydroxyproline in isolation. Therefore, while there is some scientific rationale and limited supporting data, the current evidence base is not strong, and more rigorous clinical trials are needed to confirm the efficacy of hydroxyproline supplementation for cartilage damage.

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Products containing hydroxyproline

We currently have no products on Vitabase that contain this ingredient.