Evidence supporting the use of: Methylsulfonylmethane (MSM)
For the health condition: Cartilage Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Methylsulfonylmethane (MSM) is an organosulfur compound that has gained popularity as a dietary supplement for joint health, including the support and treatment of cartilage damage. The scientific evidence supporting MSM's use in this context is moderate but not robust, meriting a rating of 2 out of 5. Several small-scale randomized controlled trials and animal studies have investigated MSM’s effects on osteoarthritis and joint pain, conditions often associated with cartilage degradation. These studies suggest that MSM may reduce joint pain, inflammation, and improve physical function. For example, a 2006 double-blind study published in Osteoarthritis and Cartilage found that MSM supplementation over 12 weeks resulted in modest improvements in pain and physical function in patients with knee osteoarthritis, though it did not directly assess cartilage repair.

The proposed mechanisms by which MSM may benefit cartilage include its anti-inflammatory properties, ability to reduce oxidative stress, and potential to support collagen and proteoglycan synthesis—key components of cartilage tissue. However, direct evidence showing that MSM can repair or regenerate damaged cartilage is lacking. Most studies focus on symptomatic relief rather than structural improvements to cartilage. Larger, high-quality clinical trials with imaging or histological endpoints are needed to confirm any definitive cartilage-protective effects.

In summary, while there is some scientific basis for MSM’s use in joint-related conditions, the evidence specifically for its role in treating or supporting cartilage damage is limited and not conclusive.

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