Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol is a polyphenolic compound found in grapes, berries, and peanuts, and has attracted attention for its potential benefits in joint health, particularly regarding cartilage damage. Scientific interest in resveratrol for cartilage protection is based on preclinical studies rather than traditional use; there is little evidence that resveratrol was historically used for joint or cartilage issues in traditional medicine. The scientific rationale for resveratrol's use stems primarily from laboratory and animal studies. In vitro (cell culture) experiments have shown that resveratrol can inhibit the production of inflammatory mediators and matrix-degrading enzymes (such as MMPs and ADAMTS) in cartilage cells (chondrocytes). These effects are thought to be mediated through pathways such as NF-κB inhibition, leading to reduced inflammation and decreased breakdown of cartilage matrix. In animal models of osteoarthritis, resveratrol supplementation has been reported to reduce cartilage degradation and improve joint function. However, evidence in humans remains very limited. Most clinical trials using resveratrol have focused on other aspects of health (such as cardiovascular or metabolic effects), with only a few small studies addressing joint pain or osteoarthritis. These preliminary trials suggest some potential benefit, but are not yet sufficient to conclusively establish effectiveness for cartilage repair or protection. In summary, while there is scientific interest and some promising preclinical evidence, robust clinical data in humans is lacking. Thus, the current level of evidence supporting resveratrol for cartilage damage is modest.

More about resveratrol
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Other ingredients used for Cartilage Damage

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