Evidence supporting the use of: Cyanidin-3-glucoside
For the health condition: Cataracts

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cyanidin-3-glucoside (C3G) is an anthocyanin found in various fruits and vegetables, particularly berries. Its use for supporting or treating cataracts is primarily based on preclinical scientific studies rather than traditional medicine or robust human clinical trials. Several animal and in vitro studies have explored the potential protective effects of C3G against cataract formation, mainly due to its antioxidant properties. For example, research published in experimental models suggests that C3G can reduce oxidative stress in the lens, which is a key factor in cataract development. In rat models, administration of C3G has been shown to attenuate lens opacity induced by agents such as selenite, likely by scavenging reactive oxygen species and preventing lipid peroxidation.

However, direct clinical evidence in humans is lacking. No large-scale or well-designed clinical trials have established its efficacy in preventing or treating cataracts in patients. Most available evidence is limited to laboratory studies or animal research, which, while promising, do not guarantee similar effects in humans due to differences in metabolism, dosing, and complexity of cataract formation. Therefore, the evidence supporting its use is considered preliminary, and its efficacy for cataracts in humans remains unproven at this time.

In summary, while there is some scientific rationale and early-stage evidence for the use of cyanidin-3-glucoside in cataract prevention, robust clinical validation is currently lacking, and its use should be considered experimental.

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