Evidence supporting the use of: Flavonoid (mixture)
For the health condition: Cataracts

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavonoids are a diverse group of plant polyphenols found in fruits, vegetables, tea, and other dietary sources. Their use in supporting or treating cataracts is primarily justified by preclinical and some epidemiological scientific evidence, not by long-standing traditional medical practices. Flavonoids exhibit antioxidant and anti-inflammatory properties, which have been hypothesized to protect lens proteins and fibers from oxidative damage—a key mechanism in cataract formation. Laboratory studies and animal models have shown that certain flavonoids (such as quercetin, rutin, and catechins) can reduce oxidative stress in lens tissue and may inhibit cataractogenesis induced by various insults (e.g., UV radiation, diabetes, or oxidative chemicals). Some small observational studies in humans suggest an association between higher dietary flavonoid intake and a lower risk of cataract development, but these studies are limited by confounding factors and do not establish causality.

However, robust clinical trials evaluating flavonoid mixtures as a treatment or preventive intervention for cataracts in humans are lacking. Most evidence comes from laboratory or animal research, which does not always translate to clinical efficacy in humans. No major ophthalmological societies currently recommend flavonoid supplementation as a standard therapy for cataracts. Therefore, while there is some scientific rationale and preliminary evidence supporting their potential benefit, the overall level of evidence is low (rated 2 out of 5). More rigorous human studies are needed to confirm any clinical effect.

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