Evidence supporting the use of: Beta-carotene
For the health condition: Cervical Dysplasia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Beta-carotene, a precursor to vitamin A and an antioxidant, has been studied for its potential role in supporting or treating cervical dysplasia (precancerous changes in the cervix) due to its involvement in cell differentiation and immune function. Scientific interest in beta-carotene for cervical dysplasia emerged from observational studies that noted an association between low serum beta-carotene or vitamin A levels and an increased risk of cervical intraepithelial neoplasia (CIN). Several small randomized controlled trials in the 1980s and 1990s investigated whether beta-carotene supplementation could regress cervical dysplasia.

Results from these studies have been mixed. Some trials suggested a modest effect—such as a 1992 study that showed slightly higher regression rates of dysplasia with beta-carotene supplementation compared to placebo. However, subsequent larger and more rigorous studies did not confirm a significant benefit. For example, a 1998 double-blind study found no statistically significant difference in regression rates between the beta-carotene and placebo groups. A 2003 Cochrane review concluded that there is insufficient evidence to support the effectiveness of beta-carotene supplementation for treating cervical dysplasia.

Thus, while there is scientific rationale for investigating beta-carotene and some limited early evidence, current scientific consensus does not support its use as a primary or adjunctive treatment for cervical dysplasia. The overall quality and consistency of evidence is low, and major guidelines do not recommend beta-carotene supplementation for this condition.

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