Diindolylmethane (DIM) is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables like broccoli and cabbage. The use of DIM for cervical dysplasia is supported by some scientific studies, though the evidence is moderate rather than definitive. Cervical dysplasia, often caused by persistent infection with high-risk human papillomavirus (HPV) types, is a precancerous condition involving abnormal changes to the cells on the cervix.

Research suggests that DIM may influence estrogen metabolism and exert anti-viral and anti-proliferative effects, which potentially contribute to its benefit in cervical dysplasia. Several small clinical studies and pilot trials have shown that oral supplementation with DIM or its precursor, indole-3-carbinol, may lead to regression of cervical intraepithelial neoplasia (CIN) and facilitate HPV clearance. For example, a randomized controlled trial published in the Gynecologic Oncology (2004) indicated that indole-3-carbinol supplementation led to regression of CIN II/III lesions in a significant proportion of women compared to placebo.

However, these studies are generally limited by small sample sizes and variable formulations (DIM vs. indole-3-carbinol), and not all trials have shown significant effects. The mechanism of action is still under investigation, but proposed pathways include modulation of estrogen metabolism and enhancement of immune response to HPV. Overall, while there is scientific rationale and some clinical evidence, more large-scale and long-term studies are needed to establish DIM as a standard therapy for cervical dysplasia.