Relationship: Chemical Poisoning and alpha lipoic acid

Evidence supporting the use of: Alpha lipoic acid
For the health condition: Chemical Poisoning

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Source of validity: Scientific
Rating (out of 5): 3

Alpha lipoic acid (ALA) is primarily justified for use in chemical poisoning based on scientific evidence, though its application is limited to specific toxic exposures. ALA is a potent antioxidant and metal chelator, properties that have prompted its use in poisonings involving heavy metals and some specific chemicals. Most notably, ALA has been used for the treatment of acute poisoning by Amanita phalloides (death cap mushroom), where it was included as part of the “Milan protocol.” Several case reports and small studies from the 1970s and 1980s suggested improved survival with ALA administration, although more recent reviews have questioned its efficacy compared to modern supportive care and other antidotes like silibinin. In addition, ALA’s chelating activity has led to exploration in heavy metal poisoning (e.g., mercury, arsenic, lead), but robust clinical evidence is lacking and standard chelation agents are preferred.

Animal studies and in vitro data support ALA’s ability to reduce oxidative stress and cellular damage from various toxicants, but controlled human trials are sparse. As a result, ALA is not a first-line therapy for most poisonings, but its scientific rationale and historical use in specific cases justify its inclusion as a supportive agent. Its use should be considered experimental and always under the supervision of a medical professional.

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Evidence supporting the use of: Alpha lipoic acid
For the health condition: Chemical Poisoning

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Evidence supporting the use of: Alpha lipoic acidFor the health condition: Chemical Poisoning

Table of Contents

Synopsis

Other ingredients used for Chemical Poisoning

Other health conditions supported by alpha lipoic acid

Products containing alpha lipoic acid

Evidence supporting the use of: Alpha lipoic acid
For the health condition: Chemical Poisoning