Evidence supporting the use of: Cysteine
For the health condition: Chemical Poisoning

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Cysteine, particularly in the form of N-acetylcysteine (NAC), is scientifically validated for use in certain types of chemical poisoning, most notably acetaminophen (paracetamol) overdose. NAC serves as a precursor to glutathione, a critical antioxidant in the body, and replenishes glutathione stores that are depleted in the liver during toxic exposures. This allows the body to effectively detoxify harmful metabolites and mitigate liver damage. NAC is the standard of care for acetaminophen poisoning and is included in clinical guidelines worldwide. Its efficacy is well-supported by randomized controlled trials and decades of clinical experience, earning it a high rating for evidence in this context.

Beyond acetaminophen poisoning, NAC has also been investigated, with some supporting evidence, as an antidote for other chemical poisonings that induce oxidative stress, such as certain heavy metals (e.g., mercury) and some herbicides (e.g., paraquat). However, the evidence base for these uses is less robust, typically consisting of animal studies, case reports, or small clinical series. Cysteine itself (as an amino acid supplement) is rarely used directly; the acetylated form (NAC) is preferred due to better bioavailability and established dosing regimens.

In summary, the use of cysteine—primarily as NAC—is strongly supported by scientific evidence for treating acetaminophen poisoning and has some experimental backing for other toxic exposures, justifying a high evidence rating for specific forms of chemical poisoning.

More about Cysteine
More about Chemical Poisoning

Products containing Cysteine

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