Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha-ketoglutarate (AKG) has some scientific backing for its use in supporting chemotherapy patients, especially for reducing certain side effects. AKG is an intermediate in the Krebs cycle and plays a role in amino acid metabolism and cellular energy production. Several animal studies and a few small clinical trials suggest that AKG supplementation may help mitigate some of the toxicity associated with chemotherapy, particularly gastrointestinal mucositis (inflammation and ulceration of the digestive tract), which is a common side effect of intensive chemotherapy regimens. AKG appears to support mucosal healing and maintain intestinal barrier function, possibly due to its role as a nitrogen scavenger and its ability to reduce oxidative stress and inflammation.

One notable study in pediatric oncology found that oral supplementation with a related compound, glutamine/AKG, reduced the severity and duration of mucositis in children undergoing chemotherapy. Other research in animal models has shown that AKG can help preserve lean body mass and reduce muscle wasting, which are important considerations for patients undergoing cancer treatment. However, while these findings are promising, the number and scale of human clinical trials remain limited, and more robust, large-scale studies are needed to confirm efficacy and establish optimal dosing.

Overall, the use of AKG in chemotherapy is supported by a moderate level of scientific evidence, primarily from preclinical and early-phase human studies. It is not a traditional remedy for this purpose, nor is it entirely experimental; rather, it occupies a middle ground with mechanistic plausibility and some early clinical support.

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