Evidence supporting the use of: Alpha lactalbumin
For the health condition: Chemotherapy (reducing side effects)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Alpha-lactalbumin, a major whey protein found in milk, has attracted research interest for its potential benefits during chemotherapy, particularly in reducing side effects and supporting immune function. The scientific basis for its use centers around its high tryptophan content and its ability to form complexes (such as HAMLET—Human Alpha-lactalbumin Made LEthal to Tumor cells) that may selectively induce apoptosis in tumor cells while sparing healthy cells. Some in vitro and animal studies have shown that HAMLET can kill cancer cells and may enhance the efficacy of chemotherapy, possibly reducing required doses and associated toxicity.
Additionally, alpha-lactalbumin is a rich source of essential amino acids and bioactive peptides, which may help support immune function and improve nutritional status in patients undergoing chemotherapy, who are at risk for malnutrition and immunosuppression.
However, clinical evidence in humans is limited. Most studies have been preclinical or conducted in small cohorts, and robust, placebo-controlled clinical trials specifically evaluating alpha-lactalbumin for mitigating chemotherapy side effects are lacking. While the mechanistic rationale is promising and animal data are supportive, more research is needed to establish efficacy and safety in cancer patients. Therefore, scientific evidence exists but is currently limited, justifying a moderate-low evidence rating.
More about Alpha lactalbumin
More about Chemotherapy (reducing side effects)
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AHCC
Alkylglycerols
Aloe vera
Alpha Glucans
Alpha lactalbumin
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
anthocyanins
Antrodia camphorata
astaxanthin
astragalus
Baikal Skullcap
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benzyl isothiocyanate
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
black cumin
black currant
blueberry
Boswellic Acid
branched-chain amino acids
bromelain
C-phycocyanin
cannabidiol
cannabigerol
Cannabis sativa oil
caryophyllene
chamomile
chlorella
Clostridium butyricum
Codonopsis
coenzyme Q10 (CoQ10)
coix
colostrum
curcumin
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cyclodextrin
d-alpha tocopherol
dithiolthiones
ergothioneine
fish oil
folinic acid
fucoidan
ginger
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grape
green tea
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hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
HMB hydroxymethylbutyrate
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hydroxymethylbutyrate
Hyphomycetes
L-alanyl-L-glutamine
L-carnosine
L-cysteine
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Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus lactis
Lactobacillus plantarum
Lactoferrin
lactoglobulin
Lentinan
Lentinula edodes mycelia
licorice root
lion's mane
luteolin
Marine lipid
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Milk Protein
Milk thistle
Mistletoe
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Peptides
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phytocannabinoids
polysaccharides
pomegranate
probiotics
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
Saccharomyces boulardii
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selenium
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shiitake mushroom
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soy isoflavones
spirulina
streptococcus thermophilus
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Thymidine
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tributyrin
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turmeric
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vitamin B6
vitamin C
vitamin E
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Nervousness
Stress