Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cannabis sativa oil, which contains cannabinoids such as THC and CBD, has been increasingly studied for its potential to alleviate some of the side effects associated with chemotherapy, including nausea, vomiting, loss of appetite, pain, and anxiety. The scientific justification for its use primarily centers on its antiemetic (anti-nausea) and appetite-stimulating properties. Clinical studies and systematic reviews have shown that cannabinoids can be effective in reducing chemotherapy-induced nausea and vomiting, particularly in patients who do not respond well to standard antiemetic medications. For example, a 2015 Cochrane review concluded that cannabinoids may be useful as adjunctive treatment for chemotherapy-induced nausea and vomiting, though they are not always more effective than newer pharmaceutical antiemetics.

The mechanism is thought to involve interaction with the body’s endocannabinoid system, particularly the CB1 receptors in the central nervous system, which play a role in regulating nausea and vomiting. Some studies also suggest potential benefits for pain reduction and improved appetite, though the evidence in these areas is less robust.

However, the evidence for cannabis sativa oil specifically (as opposed to isolated cannabinoids or pharmaceutical preparations) is more limited, and there is variability in product composition. Side effects such as dizziness, dry mouth, and cognitive impairment can occur. Overall, while scientific evidence exists to justify its use, it is not uniformly strong and further research is needed to establish standardized dosing, efficacy, and safety profiles.

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