Evidence supporting the use of: Dithiolthiones
For the health condition: Chemotherapy (reducing side effects)

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Dithiolthiones, particularly 1,2-dithiol-3-thione derivatives such as oltipraz, have been studied for their potential to reduce chemotherapy side effects due to their antioxidant and chemoprotective properties. The primary scientific rationale comes from their ability to induce phase II detoxifying enzymes (e.g., glutathione S-transferases) via activation of the Nrf2 pathway, which can enhance cellular defense mechanisms against oxidative stress generated by chemotherapy agents. Several preclinical studies in animal models have demonstrated that dithiolthiones can protect normal tissues from chemotherapy-induced toxicity (such as nephrotoxicity and hepatotoxicity) without reducing the anti-cancer efficacy of the chemotherapeutic drugs. However, clinical evidence in humans is limited. While some early-phase clinical trials have investigated oltipraz as a chemopreventive agent or as support during chemotherapy, results have been inconclusive, with concerns about side effects at higher doses and inconsistent benefit in reducing chemotherapy toxicity. There is no widespread clinical adoption or guideline-based recommendation for the use of dithiolthiones to support chemotherapy in patients. Therefore, while there is a plausible mechanistic basis and promising preclinical data, human evidence remains limited and inconclusive, justifying a moderate-low rating of 2 out of 5 for the evidence supporting this use.

More about dithiolthiones
More about Chemotherapy (reducing side effects)

Other ingredients used for Chemotherapy (reducing side effects)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Acemannan
AHCC
Alkylglycerols
Aloe vera
Alpha Glucans
Alpha lactalbumin
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
anthocyanins
Antrodia camphorata
astaxanthin
astragalus
Baikal Skullcap
BCAA
benzyl isothiocyanate
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
black cumin
black currant
blueberry
Boswellic Acid
branched-chain amino acids
bromelain
C-phycocyanin
cannabidiol
cannabigerol
Cannabis sativa oil
caryophyllene
chamomile
chlorella
Clostridium butyricum
Codonopsis
coenzyme Q10 (CoQ10)
coix
colostrum
curcumin
Curcuminoid
cyclodextrin
d-alpha tocopherol
dithiolthiones
ergothioneine
fish oil
folinic acid
fucoidan
ginger
Glutamine
Glutathione
grape
green tea
Haematococcus pluvialis
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
HMB hydroxymethylbutyrate
Honokiol
hydroxymethylbutyrate
Hyphomycetes
L-alanyl-L-glutamine
L-carnosine
L-cysteine
L-glutamine
L-glutathione
L-glycine
L-taurine
Lactobacillus
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus lactis
Lactobacillus plantarum
Lactoferrin
lactoglobulin
Lentinan
Lentinula edodes mycelia
licorice root
lion's mane
luteolin
Marine lipid
Matcha
Melatonin
Mesima
Methylselenocysteine
Milk Protein
Milk thistle
Mistletoe
Mushroom
N-acetyl-cysteine (NAC)
Oldenlandia diffusa
Palmitoylethanolamide (PEA)
Peptides
Phenethyl isothiocyanate (PEITC)
phytocannabinoids
polysaccharides
pomegranate
probiotics
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
Saccharomyces boulardii
Saccharomyces cerevisiae
selenium
Selenomethionine
shiitake mushroom
Silychristin
soy isoflavones
spirulina
streptococcus thermophilus
Sulforaphane
Thymidine
Thymoquinone
tributyrin
Turkey tail mushroom
turmeric
Typhonium flagelliforme
Verbascoside
vitamin B6
vitamin C
vitamin E
Whey protein
Zinc

Products containing dithiolthiones

We currently have no products on Vitabase that contain this ingredient.