Evidence supporting the use of: Ergothioneine
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ergothioneine is a naturally occurring antioxidant amino acid found in mushrooms and some other foods. Its potential role in reducing the side effects of chemotherapy is an area of emerging scientific interest, but clinical evidence in humans remains limited. Preclinical studies (cell and animal models) have shown that ergothioneine can protect cells from oxidative stress and reduce cellular damage caused by chemotherapeutic agents such as doxorubicin and cisplatin. These findings suggest a potential for ergothioneine to mitigate some chemotherapy-induced toxicities, particularly those related to oxidative damage (e.g., cardiotoxicity, nephrotoxicity).

However, the available evidence is largely restricted to laboratory studies. Human clinical trials specifically testing the effects of ergothioneine supplementation in cancer patients undergoing chemotherapy are lacking as of mid-2024. Some research highlights ergothioneine’s ability to accumulate in tissues exposed to high oxidative stress, further supporting its theoretical utility in this context. Additionally, a few review articles have proposed ergothioneine as a candidate for adjunct therapy during chemotherapy based on its antioxidant and cytoprotective properties, but they emphasize the need for robust clinical trials.

In summary, while there is preliminary scientific rationale and experimental data supporting ergothioneine’s potential to reduce chemotherapy side effects, direct clinical validation is currently insufficient. Thus, its use for this purpose is not yet evidence-based in clinical practice.

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Other ingredients used for Chemotherapy (reducing side effects)

aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
Dithiolthiones
Ergothioneine
Milk Protein
Mistletoe

Products containing Ergothioneine

We currently have no products on Vitabase that contain this ingredient.