Evidence supporting the use of: Fucoidan
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fucoidan, a sulfated polysaccharide primarily derived from brown seaweed, has attracted interest for its potential to support patients undergoing chemotherapy, particularly in mitigating some of the treatment's adverse effects. While there is evidence from in vitro and animal studies suggesting fucoidan may have immunomodulatory, anti-inflammatory, and cytoprotective properties, the clinical evidence in humans remains limited and preliminary.

A handful of small clinical trials, mainly conducted in East Asia, have examined fucoidan as an adjunct to chemotherapy in cancer patients. For example, a few studies in patients with advanced cancer reported that oral fucoidan supplementation was associated with improved quality of life and reductions in chemotherapy-induced fatigue and gastrointestinal side effects. Some studies also suggested that fucoidan might enhance immune function or help maintain white blood cell counts during chemotherapy. However, these studies often suffer from methodological limitations, such as small sample sizes, lack of blinding, and short follow-up periods.

Systematic reviews and meta-analyses have concluded that while fucoidan appears safe and may provide some supportive benefits, the overall quality of evidence is low, and larger, well-designed randomized controlled trials are needed. Therefore, the use of fucoidan to reduce chemotherapy side effects is supported by some scientific evidence, but it is not robust or conclusive at this stage.

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Other ingredients used for Chemotherapy (reducing side effects)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Acemannan
AHCC
Alkylglycerols
Aloe vera
Alpha Glucans
Alpha lactalbumin
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
anthocyanins
Antrodia camphorata
astaxanthin
astragalus
Baikal Skullcap
BCAA
benzyl isothiocyanate
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
black cumin
black currant
blueberry
Boswellic Acid
branched-chain amino acids
bromelain
C-phycocyanin
cannabidiol
cannabigerol
Cannabis sativa oil
caryophyllene
chamomile
chlorella
Clostridium butyricum
Codonopsis
coenzyme Q10 (CoQ10)
coix
colostrum
curcumin
Curcuminoid
cyclodextrin
d-alpha tocopherol
dithiolthiones
ergothioneine
fish oil
folinic acid
fucoidan
ginger
Glutamine
Glutathione
grape
green tea
Haematococcus pluvialis
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
HMB hydroxymethylbutyrate
Honokiol
hydroxymethylbutyrate
Hyphomycetes
L-alanyl-L-glutamine
L-carnosine
L-cysteine
L-glutamine
L-glutathione
L-glycine
L-taurine
Lactobacillus
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus lactis
Lactobacillus plantarum
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lactoglobulin
Lentinan
Lentinula edodes mycelia
licorice root
lion's mane
luteolin
Marine lipid
Matcha
Melatonin
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Milk Protein
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N-acetyl-cysteine (NAC)
Oldenlandia diffusa
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protein
pyridoxal-5-phosphate (P-5-P)
quercetin
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resveratrol
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selenium
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shiitake mushroom
Silychristin
soy isoflavones
spirulina
streptococcus thermophilus
Sulforaphane
Thymidine
Thymoquinone
tributyrin
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turmeric
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vitamin B6
vitamin C
vitamin E
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Products containing fucoidan

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