Evidence supporting the use of: Glutamine
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glutamine has been investigated as a supportive therapy for patients undergoing chemotherapy, primarily to reduce certain side effects such as oral mucositis and neuropathy. The theoretical rationale is that glutamine is the most abundant amino acid in the body and serves as a key nutrient for rapidly dividing cells, including those in the gastrointestinal tract. During chemotherapy, glutamine levels can become depleted, contributing to mucosal injury and other side effects.

Several clinical trials and meta-analyses have examined glutamine supplementation in this context, with mixed results. Some studies suggest that oral glutamine may reduce the severity and duration of oral mucositis in patients receiving specific chemotherapeutic agents (such as high-dose chemotherapy for hematologic malignancies). There is also limited evidence indicating a potential reduction in chemotherapy-induced neuropathy, particularly with agents like paclitaxel or oxaliplatin. However, results are inconsistent, sample sizes are often small, and methodological quality varies.

Major guidelines, such as those from the American Society of Clinical Oncology (ASCO) and the European Society for Medical Oncology (ESMO), do not universally recommend glutamine for this purpose, citing insufficient or conflicting evidence. Additionally, there are theoretical concerns that glutamine could potentially support tumor growth, although this has not been conclusively demonstrated in clinical settings. Overall, while there is some scientific investigation supporting glutamine’s use, the evidence is limited and not definitive.

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Other ingredients used for Chemotherapy (reducing side effects)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Acemannan
AHCC
Alkylglycerols
Aloe vera
Alpha Glucans
Alpha lactalbumin
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
anthocyanins
Antrodia camphorata
astaxanthin
astragalus
Baikal Skullcap
BCAA
benzyl isothiocyanate
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
black cumin
black currant
blueberry
Boswellic Acid
branched-chain amino acids
bromelain
C-phycocyanin
cannabidiol
cannabigerol
Cannabis sativa oil
caryophyllene
chamomile
chlorella
Clostridium butyricum
Codonopsis
coenzyme Q10 (CoQ10)
coix
colostrum
curcumin
Curcuminoid
cyclodextrin
d-alpha tocopherol
dithiolthiones
ergothioneine
fish oil
folinic acid
fucoidan
ginger
Glutamine
Glutathione
grape
green tea
Haematococcus pluvialis
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
HMB hydroxymethylbutyrate
Honokiol
hydroxymethylbutyrate
Hyphomycetes
L-alanyl-L-glutamine
L-carnosine
L-cysteine
L-glutamine
L-glutathione
L-glycine
L-taurine
Lactobacillus
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus lactis
Lactobacillus plantarum
Lactoferrin
lactoglobulin
Lentinan
Lentinula edodes mycelia
licorice root
lion's mane
luteolin
Marine lipid
Matcha
Melatonin
Mesima
Methylselenocysteine
Milk Protein
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Mistletoe
Mushroom
N-acetyl-cysteine (NAC)
Oldenlandia diffusa
Palmitoylethanolamide (PEA)
Peptides
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phytocannabinoids
polysaccharides
pomegranate
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protein
pyridoxal-5-phosphate (P-5-P)
quercetin
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resveratrol
Saccharomyces boulardii
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selenium
Selenomethionine
shiitake mushroom
Silychristin
soy isoflavones
spirulina
streptococcus thermophilus
Sulforaphane
Thymidine
Thymoquinone
tributyrin
Turkey tail mushroom
turmeric
Typhonium flagelliforme
Verbascoside
vitamin B6
vitamin C
vitamin E
Whey protein
Zinc

Products containing Glutamine

We currently have no products on Vitabase that contain this ingredient.