Evidence supporting the use of: Glutamine alpha-ketoglutarate
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glutamine alpha-ketoglutarate (GAKG) is sometimes considered for use in reducing the side effects of chemotherapy, particularly for minimizing oral mucositis (mouth sores) and gastrointestinal toxicity. The rationale is based primarily on the role of glutamine, an amino acid that supports gut mucosal integrity and immune function, and alpha-ketoglutarate, a key molecule in cellular energy production and nitrogen metabolism. Some studies have shown that glutamine supplementation alone can reduce the severity and duration of mucositis in cancer patients undergoing chemotherapy or radiation therapy. However, the evidence for the specific combination of glutamine with alpha-ketoglutarate is limited. Most clinical research focuses on glutamine by itself, and while there are positive findings, results are mixed and not universally accepted in clinical guidelines. The addition of alpha-ketoglutarate is theorized to further support metabolic and tissue repair processes, but there is a lack of robust, high-quality clinical trials directly investigating GAKG in the context of chemotherapy side effect reduction. As such, while the use of glutamine (and by extension, GAKG) is grounded in some scientific rationale and preliminary evidence, the overall strength of evidence is modest, and major oncology societies do not uniformly endorse its use for this purpose. More rigorous research is needed to clarify its efficacy and safety in this setting.

More about Glutamine alpha-ketoglutarate
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Other ingredients used for Chemotherapy (reducing side effects)

aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
Dithiolthiones
Ergothioneine
Milk Protein
Mistletoe

Products containing Glutamine alpha-ketoglutarate

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