Evidence supporting the use of: Glutathione
For the health condition: Chemotherapy (reducing side effects)

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glutathione Use for Reducing Chemotherapy Side Effects: Scientific Evidence

Glutathione, a tripeptide with potent antioxidant properties, has been investigated for its ability to mitigate certain side effects of chemotherapy, particularly neurotoxicity and nephrotoxicity associated with agents like cisplatin and oxaliplatin. Scientific evidence supporting its use comes mainly from clinical trials and meta-analyses, although the strength and consistency of findings vary.

Several randomized controlled trials (RCTs) have demonstrated that intravenous glutathione can significantly reduce the incidence and severity of chemotherapy-induced peripheral neuropathy, especially in patients receiving platinum-based chemotherapy. For example, studies in patients with ovarian and colorectal cancer have shown improved neurological outcomes and a better quality of life with glutathione co-administration, without compromising the efficacy of the chemotherapy. Additionally, some data suggest a protective effect against cisplatin-induced kidney damage.

However, not all studies have found benefit, and clinical practice guidelines do not universally recommend its use due to variability in study designs, dosing regimens, and endpoints. The evidence is strongest for neuroprotection in platinum-based chemotherapy, but more large-scale, high-quality RCTs are needed to establish definitive recommendations. Overall, the current evidence base justifies a moderate rating, indicating scientific support but not yet routine standard of care.

More about Glutathione
More about Chemotherapy (reducing side effects)

Other ingredients used for Chemotherapy (reducing side effects)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Acemannan
AHCC
Alkylglycerols
Aloe vera
Alpha Glucans
Alpha lactalbumin
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
anthocyanins
Antrodia camphorata
astaxanthin
astragalus
Baikal Skullcap
BCAA
benzyl isothiocyanate
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
black cumin
black currant
blueberry
Boswellic Acid
branched-chain amino acids
bromelain
C-phycocyanin
cannabidiol
cannabigerol
Cannabis sativa oil
caryophyllene
chamomile
chlorella
Clostridium butyricum
Codonopsis
coenzyme Q10 (CoQ10)
coix
colostrum
curcumin
Curcuminoid
cyclodextrin
d-alpha tocopherol
dithiolthiones
ergothioneine
fish oil
folinic acid
fucoidan
ginger
Glutamine
Glutathione
grape
green tea
Haematococcus pluvialis
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
HMB hydroxymethylbutyrate
Honokiol
hydroxymethylbutyrate
Hyphomycetes
L-alanyl-L-glutamine
L-carnosine
L-cysteine
L-glutamine
L-glutathione
L-glycine
L-taurine
Lactobacillus
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus lactis
Lactobacillus plantarum
Lactoferrin
lactoglobulin
Lentinan
Lentinula edodes mycelia
licorice root
lion's mane
luteolin
Marine lipid
Matcha
Melatonin
Mesima
Methylselenocysteine
Milk Protein
Milk thistle
Mistletoe
Mushroom
N-acetyl-cysteine (NAC)
Oldenlandia diffusa
Palmitoylethanolamide (PEA)
Peptides
Phenethyl isothiocyanate (PEITC)
phytocannabinoids
polysaccharides
pomegranate
probiotics
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
Saccharomyces boulardii
Saccharomyces cerevisiae
selenium
Selenomethionine
shiitake mushroom
Silychristin
soy isoflavones
spirulina
streptococcus thermophilus
Sulforaphane
Thymidine
Thymoquinone
tributyrin
Turkey tail mushroom
turmeric
Typhonium flagelliforme
Verbascoside
vitamin B6
vitamin C
vitamin E
Whey protein
Zinc

Products containing Glutathione

We currently have no products on Vitabase that contain this ingredient.