Evidence supporting the use of: Honokiol
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Honokiol, a bioactive compound derived from the bark of Magnolia species, has gained attention for its potential role in supporting chemotherapy by reducing associated side effects. Preclinical studies (mainly in vitro and animal models) suggest that honokiol possesses antioxidant, anti-inflammatory, and neuroprotective properties, which may help mitigate the toxic side effects of certain chemotherapeutic agents. For example, honokiol has been shown to reduce cisplatin-induced nephrotoxicity and protect against doxorubicin-induced cardiotoxicity in animal studies. Additionally, its potential to attenuate chemotherapy-induced neuropathic pain has been reported in some rodent models.

There is also evidence that honokiol does not interfere with the anti-tumor activity of chemotherapy drugs and may even synergize with some agents. However, it is important to note that most of the available evidence comes from laboratory studies, and robust human clinical trials are lacking. There is no substantial traditional or historical use for honokiol in the context of chemotherapy support, as its application for this purpose is a relatively recent development based on modern pharmacological research.

In summary, while there is some promising preclinical evidence that honokiol may help reduce certain side effects of chemotherapy, clinical evidence in humans is currently insufficient. More high-quality randomized controlled trials are needed to confirm its safety and efficacy in this context.

More about Honokiol
More about Chemotherapy (reducing side effects)

Other ingredients used for Chemotherapy (reducing side effects)

aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
Dithiolthiones
Ergothioneine
Milk Protein
Mistletoe

Products containing Honokiol

We currently have no products on Vitabase that contain this ingredient.