Evidence supporting the use of: Hydrogen
For the health condition: Chemotherapy (reducing side effects)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Hydrogen therapy, specifically in the form of hydrogen-rich water or inhaled molecular hydrogen gas, has been investigated in recent years as a supportive treatment for patients undergoing chemotherapy. The primary rationale is based on hydrogen’s properties as a selective antioxidant. Several preclinical studies (mainly in animal models) and a small number of early-phase clinical trials have suggested that hydrogen may reduce some chemotherapy-induced side effects, such as oxidative stress, inflammation, and organ toxicity, without compromising the anticancer efficacy of the chemotherapeutic agents. For example, a 2011 pilot study published in Medical Gas Research reported that patients drinking hydrogen-rich water during radiotherapy for liver tumors experienced improved quality of life and reduced markers of oxidative stress, though the study was small and not specific to chemotherapy. Another small clinical study suggested potential benefits for oral mucositis in patients receiving chemotherapy. However, the evidence base remains weak due to small sample sizes, lack of large-scale randomized controlled trials, and variability in the methods of hydrogen administration. Most of the evidence is preclinical, and robust clinical data are lacking. Thus, while there is scientific interest and some preliminary evidence supporting hydrogen’s potential to reduce chemotherapy side effects, the current strength of evidence is low. More rigorous clinical trials are necessary to confirm efficacy and safety before hydrogen can be recommended as standard supportive care in oncology.
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