Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glycine has been investigated for its potential to reduce certain side effects of chemotherapy, particularly those related to organ toxicity (such as nephrotoxicity and hepatotoxicity). The rationale is based on its role as a non-essential amino acid that exhibits cytoprotective, anti-inflammatory, and antioxidant properties. Preclinical studies, particularly in animal models, suggest that glycine supplementation can reduce oxidative stress and inflammation, potentially protecting tissues from damage induced by chemotherapeutic agents like cisplatin and doxorubicin. For example, studies in rodents have shown that glycine can attenuate kidney and liver injury markers after chemotherapy exposure.

However, human clinical data are limited. There are very few well-controlled clinical trials assessing the efficacy and safety of L-glycine for this purpose in cancer patients. Some small pilot studies or case reports suggest potential benefit, but the evidence is not robust enough for widespread clinical recommendation. The use of glycine for chemotherapy side effect mitigation is not rooted in traditional medical practices but rather in modern experimental and mechanistic science. Therefore, while there is scientific interest and some preliminary data, the overall evidence supporting glycine supplementation to reduce chemotherapy side effects in humans is weak (rated 2/5), and further high-quality clinical trials are needed before this approach can be fully endorsed.

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