Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lion's mane mushroom (Hericium erinaceus) has attracted attention for its potential neuroprotective, anti-inflammatory, and immunomodulatory properties. Its use to support patients undergoing chemotherapy largely arises from preclinical studies and a limited number of clinical observations suggesting it may help mitigate some chemotherapy-induced side effects, such as neuropathy and immunosuppression. Several animal studies have demonstrated that lion's mane extracts can promote nerve growth factor (NGF) synthesis and support neuronal regeneration, which is relevant because chemotherapy often causes peripheral neuropathy. Additionally, lion's mane has demonstrated antioxidant and anti-inflammatory effects in vitro and in animal models, which could theoretically counteract some of the oxidative stress and inflammation caused by chemotherapy agents.

However, rigorous human clinical trials specifically examining lion's mane for reducing chemotherapy side effects are sparse. A few small-scale studies in cancer patients have noted improvements in quality of life, mood, and immune markers, but these studies are preliminary and not specific to all chemotherapy-related symptoms. There is no robust evidence yet that lion's mane can consistently reduce the severity of chemotherapy side effects in diverse patient populations. Thus, while the scientific rationale is promising and early data are encouraging, the overall strength of evidence is low (rated 2/5), and more high-quality human studies are needed to establish efficacy and safety in this context.

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