Evidence supporting the use of: N-Acetyl Cysteine
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

N-Acetyl Cysteine (NAC) is supported by scientific evidence for use in reducing certain side effects of chemotherapy, particularly chemotherapy-induced toxicity such as nephrotoxicity from cisplatin and hemorrhagic cystitis from cyclophosphamide or ifosfamide. NAC is a precursor to glutathione, a major intracellular antioxidant, and works by replenishing glutathione stores and directly scavenging free radicals. This antioxidant property is believed to help mitigate the oxidative stress and cellular damage induced by some chemotherapeutic agents.

Clinical studies and animal models have shown that NAC can reduce the incidence and severity of organ toxicities associated with chemotherapy. For example, small randomized controlled trials and observational studies suggest that NAC may lower the risk of kidney damage in patients receiving cisplatin without significantly interfering with the antitumor efficacy of the drug. Similarly, in cases of hemorrhagic cystitis, NAC has demonstrated protective effects in preclinical and early clinical studies by reducing bladder inflammation and oxidative damage.

However, large-scale, high-quality clinical trials are limited, and routine use of NAC as a chemoprotective agent is not yet standard practice. Its use is sometimes considered in specific situations or in clinical trials, especially in patients at high risk for severe toxicity. More research is required to establish optimal dosing, timing, and to confirm its safety and efficacy across different chemotherapy regimens.

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Other ingredients used for Chemotherapy (reducing side effects)

aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
Dithiolthiones
Ergothioneine
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Products containing N-Acetyl Cysteine

We currently have no products on Vitabase that contain this ingredient.