Evidence supporting the use of: Saccharomyces cerevisiae peptides
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Saccharomyces cerevisiae peptides, derived from the common baker’s yeast, have been investigated for their potential benefits in supporting cancer patients undergoing chemotherapy, particularly for their ability to reduce side effects such as mucositis, diarrhea, and immunosuppression. The scientific rationale is based on the peptides’ immunomodulatory, antioxidant, and gut barrier-protective properties. Preclinical studies (mainly in vitro and animal models) have shown that these peptides can enhance immune responses, reduce oxidative stress, and modulate inflammatory pathways. For example, some studies have demonstrated that yeast-derived beta-glucans and other peptides stimulate macrophages and promote recovery of white blood cells after chemotherapy-induced damage.

However, high-quality human clinical trials directly evaluating Saccharomyces cerevisiae peptides for reducing chemotherapy side effects are limited. Most clinical evidence is indirect, with some trials using whole yeast extracts or beta-glucans (rather than isolated peptides) to assess outcomes such as infection rates, mucositis, or quality of life. The available human data suggest potential for benefit, but results are inconsistent and further research is needed to confirm efficacy, optimal dosing, and safety. Therefore, while there is a scientific basis for their use, the overall strength of evidence is low to moderate (rated 2/5), and Saccharomyces cerevisiae peptides should not replace established supportive care measures in chemotherapy patients.

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alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
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black cumin
black currant
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branched-chain amino acids
bromelain
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chamomile
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coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
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AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
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Alkylglycerols
Bifidobacterium
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Bifidobacterium adolescentis
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Products containing Saccharomyces cerevisiae peptides

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