Relationship: Chemotherapy (reducing side effects) and selenium

Evidence supporting the use of: Selenium
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Selenium has been investigated as an adjunct therapy to reduce the side effects of chemotherapy, mainly due to its antioxidant properties and role in cellular protection. Several clinical trials and observational studies suggest that selenium supplementation may help alleviate some common adverse effects of chemotherapy, such as mucositis, myelosuppression, and hepatotoxicity. For example, some randomized controlled trials have found that selenium supplementation can reduce the incidence and severity of chemotherapy-induced toxicity in patients with cancers such as head and neck cancer, gynecological cancers, and hematological malignancies. The proposed mechanism involves selenium's ability to boost glutathione peroxidase activity and protect normal tissues from oxidative damage triggered by chemotherapeutic agents, without reducing the efficacy of the treatment itself.

However, the evidence is not uniformly strong across all studies. Some trials have failed to demonstrate significant benefits, and there are concerns regarding the optimal dosage and potential toxicity of excess selenium. Meta-analyses and systematic reviews typically conclude that selenium may offer modest benefit in reducing certain side effects, but more high-quality, large-scale clinical trials are needed to firmly establish its efficacy and safety profile in this context. At present, selenium is sometimes recommended in supportive care, but it is not universally adopted as standard practice. Overall, the use of selenium for this indication is supported by a moderate level of scientific evidence.

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Other ingredients used for Chemotherapy (reducing side effects)

aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
Dithiolthiones
Ergothioneine
Milk Protein
Mistletoe

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Evidence supporting the use of: Selenium
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Other ingredients used for Chemotherapy (reducing side effects)

Other health conditions supported by selenium

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Health Concerns

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Evidence supporting the use of: SeleniumFor the health condition: Chemotherapy (reducing side effects)

Table of Contents

Synopsis

Other ingredients used for Chemotherapy (reducing side effects)

Other health conditions supported by selenium

Products containing selenium

Evidence supporting the use of: Selenium
For the health condition: Chemotherapy (reducing side effects)