Evidence supporting the use of: Selenomethionine
For the health condition: Chemotherapy (reducing side effects)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Selenomethionine, an organic form of selenium, has been explored for its potential to reduce the side effects of chemotherapy, primarily due to its antioxidant properties and role in supporting cellular defense mechanisms. Several preclinical and small-scale clinical studies have suggested that selenium supplementation may help mitigate chemotherapy-induced toxicity, such as myelosuppression and gastrointestinal side effects. The proposed mechanism involves selenium's integration into selenoproteins, which can reduce oxidative damage and support immune function. However, the evidence supporting selenomethionine specifically (as distinct from other forms of selenium) is limited and mixed. Some randomized controlled trials have indicated potential benefits in reducing side effects like oral mucositis and improving overall tolerance to chemotherapy. For example, a few studies in patients with head and neck cancer or gynecological cancers reported reduced severity of mucositis and improved antioxidant status. Nevertheless, other trials have failed to show significant benefits, and concerns remain about the safety of high-dose selenium supplementation, especially in populations not selenium-deficient. Major oncology guidelines do not currently recommend routine selenium supplementation during chemotherapy due to insufficient large-scale, high-quality evidence. In summary, while there is a scientific rationale and some early supportive data, the overall level of evidence remains low (rated 2/5), and further research is needed before selenomethionine can be routinely recommended to reduce chemotherapy side effects.
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alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
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astaxanthin
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caryophyllene
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Other health conditions supported by Selenomethionine
Cancer (prevention)Cancer Treatment (reducing side effects)
Chemotherapy (reducing side effects)
Hair (loss or thinning)
Hypothyroid
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Liver Detoxification