Evidence supporting the use of: Silychristin
For the health condition: Chemotherapy (reducing side effects)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Silychristin is one of the main flavonolignans found in silymarin, an extract from the seeds of Silybum marianum (milk thistle). Silymarin, and by extension silychristin, has been investigated for its potential to reduce chemotherapy-induced side effects, particularly hepatotoxicity. The scientific evidence is limited but promising in preclinical models. Several in vitro and animal studies suggest silymarin and its constituents, including silychristin, possess antioxidant, anti-inflammatory, and cytoprotective properties that may protect healthy cells from the damaging effects of chemotherapeutic agents like doxorubicin and cisplatin.
Clinical trials specifically evaluating silychristin are lacking; most human studies use silymarin as a complex mixture. While some small trials of silymarin in cancer patients have shown reductions in liver enzyme elevations and some improvement in quality of life, these findings cannot be wholly attributed to silychristin alone. There is also concern that antioxidant supplements may theoretically interfere with the efficacy of some chemotherapies, although evidence is mixed. Thus, while there is a scientific rationale and some preclinical support for silychristin’s protective effects during chemotherapy, robust clinical data are lacking. The evidence for its use is therefore rated as 2 out of 5, indicating preliminary but insufficient support for routine clinical use in this context.
More about Silychristin
More about Chemotherapy (reducing side effects)
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AHCC
Alkylglycerols
Aloe vera
Alpha Glucans
Alpha lactalbumin
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-lipoic acid
amino acids
anthocyanins
Antrodia camphorata
astaxanthin
astragalus
Baikal Skullcap
BCAA
benzyl isothiocyanate
beta caryophyllene
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
black cumin
black currant
blueberry
Boswellic Acid
branched-chain amino acids
bromelain
C-phycocyanin
cannabidiol
cannabigerol
Cannabis sativa oil
caryophyllene
chamomile
chlorella
Clostridium butyricum
Codonopsis
coenzyme Q10 (CoQ10)
coix
colostrum
curcumin
Curcuminoid
cyclodextrin
d-alpha tocopherol
dithiolthiones
ergothioneine
fish oil
folinic acid
fucoidan
ginger
Glutamine
Glutathione
grape
green tea
Haematococcus pluvialis
hemp
hemp oil
herbal blend (proprietary)
hericium mushroom
HMB hydroxymethylbutyrate
Honokiol
hydroxymethylbutyrate
Hyphomycetes
L-alanyl-L-glutamine
L-carnosine
L-cysteine
L-glutamine
L-glutathione
L-glycine
L-taurine
Lactobacillus
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus lactis
Lactobacillus plantarum
Lactoferrin
lactoglobulin
Lentinan
Lentinula edodes mycelia
licorice root
lion's mane
luteolin
Marine lipid
Matcha
Melatonin
Mesima
Methylselenocysteine
Milk Protein
Milk thistle
Mistletoe
Mushroom
N-acetyl-cysteine (NAC)
Oldenlandia diffusa
Palmitoylethanolamide (PEA)
Peptides
Phenethyl isothiocyanate (PEITC)
phytocannabinoids
polysaccharides
pomegranate
probiotics
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
Saccharomyces boulardii
Saccharomyces cerevisiae
selenium
Selenomethionine
shiitake mushroom
Silychristin
soy isoflavones
spirulina
streptococcus thermophilus
Sulforaphane
Thymidine
Thymoquinone
tributyrin
Turkey tail mushroom
turmeric
Typhonium flagelliforme
Verbascoside
vitamin B6
vitamin C
vitamin E
Whey protein
Zinc
Other health conditions supported by Silychristin
Chemotherapy (reducing side effects)Cirrhosis of the Liver
Diabetes
Fatty Liver Disease
Free Radical Damage
Hepatitis
Inflammation
Liver Detoxification