Evidence supporting the use of: SOD (Superoxide Dismutase, antioxidant activity)
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Superoxide dismutase (SOD) is an enzyme with potent antioxidant activity, catalyzing the dismutation of superoxide radicals into oxygen and hydrogen peroxide. Its use as a supportive therapy during chemotherapy is primarily justified by scientific rationale rather than longstanding tradition. Chemotherapy can induce oxidative stress and generate reactive oxygen species (ROS), contributing to both its anti-cancer effects and the collateral damage to healthy tissues, which results in side effects such as mucositis, cardiotoxicity, and neurotoxicity. Preclinical studies (in vitro and animal models) have demonstrated that SOD and SOD mimetics can reduce oxidative tissue injury and inflammation caused by certain chemotherapeutic agents. Some small clinical trials and pilot studies have evaluated SOD or SOD mimetics (such as orgotein) to mitigate chemotherapy-induced side effects, particularly mucositis and soft tissue toxicity, with mixed results. However, the available clinical evidence is limited in scale and quality, and there remains concern that systemic antioxidant therapy could potentially interfere with the efficacy of chemotherapy by protecting cancer cells as well as normal tissues from ROS-mediated damage. In summary, while there is a sound biochemical basis and some early-stage evidence supporting the use of SOD for reducing chemotherapy side effects, large-scale, high-quality clinical trials are lacking. Therefore, the overall scientific validation is weak (rated 2/5), and routine clinical use is not widely established or endorsed in oncology guidelines.

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Other ingredients used for Chemotherapy (reducing side effects)

aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
Dithiolthiones
Ergothioneine
Milk Protein
Mistletoe

Products containing SOD (Superoxide Dismutase, antioxidant activity)

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