Evidence supporting the use of: Sulforophane
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

There is emerging scientific evidence suggesting that sulforaphane, a compound found in cruciferous vegetables like broccoli, may help support patients undergoing chemotherapy by reducing certain side effects and enhancing chemotherapy efficacy. Preclinical studies have demonstrated sulforaphane’s antioxidant and anti-inflammatory properties, which may help mitigate chemotherapy-induced toxicity in normal tissues. For example, animal studies and in vitro research have shown that sulforaphane can protect against cisplatin-induced nephrotoxicity and doxorubicin-induced cardiotoxicity, potentially by activating the Nrf2 pathway, which regulates cellular antioxidant responses.

Additionally, sulforaphane has been studied for its ability to sensitize cancer cells to chemotherapeutic agents, potentially allowing for lower doses of chemotherapy and thereby reducing side effects. However, clinical evidence in humans is currently limited. Small pilot studies, such as those involving broccoli sprout extracts in cancer patients, have reported some improvements in markers of oxidative stress, but robust, large-scale clinical trials are lacking.

In summary, while preclinical data and early clinical research provide a scientific rationale for sulforaphane’s use alongside chemotherapy, the overall level of evidence is modest. More well-designed human trials are needed to confirm its efficacy and safety for reducing chemotherapy side effects.

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Other ingredients used for Chemotherapy (reducing side effects)

aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
Dithiolthiones
Ergothioneine
Milk Protein
Mistletoe

Products containing Sulforophane

We currently have no products on Vitabase that contain this ingredient.