Evidence supporting the use of: Thymoquinone
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Thymoquinone, the main bioactive constituent of Nigella sativa (black seed), has been studied for its potential to reduce chemotherapy-induced side effects. Preclinical studies (in vitro and animal models) suggest that thymoquinone exhibits antioxidant, anti-inflammatory, and cytoprotective properties, which may help mitigate some toxicities associated with chemotherapy, such as nephrotoxicity, hepatotoxicity, and hematological damage. For example, several rodent studies have shown that thymoquinone can reduce the severity of cisplatin-induced nephrotoxicity and doxorubicin-induced cardiotoxicity, likely by decreasing oxidative stress and modulating inflammatory pathways.

Despite these promising findings, robust clinical data in humans are limited. A handful of small-scale clinical trials and case reports have explored the use of Nigella sativa extracts or oil in cancer patients, but studies specifically isolating thymoquinone and focusing on chemotherapy side effect reduction are sparse. Most available evidence remains preclinical, and there is a lack of large, well-designed randomized controlled trials in humans.

In summary, while there is a scientific rationale and encouraging preclinical evidence suggesting thymoquinone may help reduce certain chemotherapy side effects, clinical validation in human populations is not yet strong. Thus, the overall evidence supporting its use for this purpose is moderate-to-weak at present (rated 2/5).

More about Thymoquinone
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Other ingredients used for Chemotherapy (reducing side effects)

aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
Dithiolthiones
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Products containing Thymoquinone

We currently have no products on Vitabase that contain this ingredient.