Typhonium flagelliforme, also known as "rodent tuber" or "Keladi tikus," has a long history of use in traditional medicine, especially in Southeast Asia and Malaysia. Traditionally, it has been used by local healers as a herbal remedy for various ailments, including cancer. The primary rationale for its use alongside chemotherapy is its reputed ability to help detoxify the body, reduce the side effects of chemotherapy (such as nausea, fatigue, and immune suppression), and enhance overall wellbeing. These claims are based on anecdotal evidence and ethnobotanical records rather than on robust clinical trials.

Scientific studies investigating Typhonium flagelliforme are limited and mostly preclinical. Some laboratory studies have indicated the plant may possess cytotoxic and antioxidant properties, which could theoretically be beneficial in supporting the body during chemotherapy. However, there is a lack of high-quality human clinical trials demonstrating that it effectively reduces chemotherapy side effects. As such, the evidence supporting its use for this purpose is weak and primarily rooted in traditional practices rather than established scientific validation.

In summary, while Typhonium flagelliforme is traditionally used to support cancer patients undergoing chemotherapy, its efficacy and safety for this specific purpose have not been conclusively demonstrated in scientific studies.