Evidence supporting the use of: Vitamin B9 (Calcium Folinate)
For the health condition: Chemotherapy (reducing side effects)
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Calcium folinate (also known as leucovorin or folinic acid) is scientifically validated for use in supporting and treating certain side effects of chemotherapy, particularly those associated with methotrexate and 5-fluorouracil (5-FU) regimens. Methotrexate is a chemotherapy agent that works by inhibiting dihydrofolate reductase, an enzyme necessary for DNA synthesis, which can also affect normal, healthy cells and lead to side effects such as myelosuppression and mucositis. Calcium folinate acts as a "rescue" agent by providing a form of folate that bypasses this enzymatic block, thereby protecting healthy cells from methotrexate toxicity without interfering with its anti-cancer efficacy. This use is known as "leucovorin rescue" and is a standard, evidence-based component of high-dose methotrexate protocols.
Additionally, calcium folinate is used in combination with 5-FU to enhance the anti-cancer effects of 5-FU in colorectal and other cancers. It stabilizes the binding of 5-FU's metabolite (FdUMP) to thymidylate synthase, increasing the cytotoxic effect on cancer cells. Numerous randomized controlled trials and meta-analyses confirm both roles of calcium folinate in modern oncology practice. Clinical guidelines from major cancer organizations (e.g., NCCN, ASCO) recommend its use. Thus, its application in chemotherapy is strongly supported by high-quality scientific evidence.
More about Vitamin B9 (Calcium Folinate)
More about Chemotherapy (reducing side effects)
Other ingredients used for Chemotherapy (reducing side effects)
aloe veraalpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
Dithiolthiones
Ergothioneine
Milk Protein
Mistletoe
Other health conditions supported by Vitamin B9 (Calcium Folinate)
AnemiaCancer Treatment (reducing side effects)
Chemotherapy (reducing side effects)
Depression
Leukemia
Pregnancy (herbs and supplements for)