Evidence supporting the use of: Vitamin E (alpha-tocopherol succinate)
For the health condition: Chemotherapy (reducing side effects)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E (particularly the alpha-tocopherol succinate form) has been investigated for its potential to reduce certain side effects of chemotherapy, most notably chemotherapy-induced peripheral neuropathy (CIPN), which is a common and sometimes dose-limiting toxicity of several chemotherapeutic drugs (e.g., cisplatin, paclitaxel). The scientific rationale is based on Vitamin E’s antioxidant properties, which may help counteract the oxidative stress and nerve damage caused by some chemotherapy agents. Several randomized controlled trials and meta-analyses have evaluated Vitamin E supplementation (generally at doses of 300-600 mg/day) for this purpose. For example, a 2021 systematic review and meta-analysis (Zhang et al., Support Care Cancer) found that Vitamin E supplementation was associated with a reduction in the incidence and severity of CIPN in some studies, though results were not uniformly positive and some studies showed no significant benefit. Additionally, there is limited evidence regarding Vitamin E's impact on other chemotherapy-related side effects, such as mucositis or cardiotoxicity, with most research focusing on neuropathy. However, concerns remain regarding the potential for antioxidants, including Vitamin E, to interfere with the efficacy of chemotherapy by protecting not just healthy cells but also cancer cells from oxidative damage. Due to inconsistent evidence and these theoretical risks, current oncology guidelines do not universally recommend Vitamin E supplementation during chemotherapy, but it may be considered in select cases under medical supervision. Overall, there is moderate (evidence rating: 3/5) scientific support specifically for reducing chemotherapy-induced neuropathy, but not for all chemotherapy side effects.

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Other ingredients used for Chemotherapy (reducing side effects)

aloe vera
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
amino acids
anthocyanins
astaxanthin
astragalus
beta caryophyllene
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
black cumin
black currant
blueberry
branched-chain amino acids
bromelain
cannabis sativa oil
chamomile
chlorella
coenzyme Q10 (CoQ10)
colostrum
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
fish oil
ginger
grape
green tea
hemp oil
l-alanyl-l-glutamine
l-carnosine
l-cysteine
l-glutamine
l-glutathione
l-glycine
l-taurine
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus lactis
lactoferrin
lentinula edodes mycelia
licorice root
lion's mane
luteolin
marine lipid
matcha
melatonin
milk thistle
n-acetyl-cysteine (NAC)
pectin
phytocannabinoids
pomegranate
protein
pyridoxal-5-phosphate (P-5-P)
quercetin
reishi mushroom
resveratrol
saccharomyces boulardii
selenium
shiitake mushroom
spirulina
streptococcus thermophilus
tributyrin
turkey tail mushroom
vitamin B6
vitamin C
vitamin E
whey protein
zinc
coix
herbal blend (proprietary)
soy isoflavones
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alpha Glucans
Antrodia camphorata
AHCC
Alpha-Lipoic Acid
Alpha lactalbumin
Acemannan
Alkylglycerols
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Bifidobacterium animalis
Bifidobacteria
BCAA
benzyl isothiocyanate
Caryophyllene
Codonopsis
Curcuminoid
C-Phycocyanin
Cannabidiol
Clostridium butyricum
Cannabigerol
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Products containing Vitamin E (alpha-tocopherol succinate)

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