Arani (Premna integrifolia), also known in Ayurveda as "Agnimantha," has been traditionally used in various formulations for cardiovascular health and chest pain ("hridroga" in Sanskrit). In classical Ayurvedic texts such as Charaka Samhita and Sushruta Samhita, Arani is cited as an ingredient in polyherbal preparations intended to balance "Vata" and "Kapha" doshas, which are believed to contribute to chest discomfort and heart conditions. The plant is considered to have anti-inflammatory, analgesic, and mild cardiotonic properties according to traditional Ayurvedic pharmacology.

However, scientific validation for the use of Arani specifically for chest pain is limited. While some laboratory and animal studies have explored the antioxidant and anti-inflammatory effects of Premna integrifolia extracts, direct clinical evidence in humans for relief of chest pain (angina or non-cardiac) is lacking. No randomized controlled trials or robust human studies have evaluated its efficacy for this specific indication. Current usage in Ayurveda is based on centuries of empirical observation and textual tradition rather than modern clinical research.

In summary, the justification for using Arani in the treatment or support of chest pain is primarily traditional, with minimal to no contemporary scientific evidence directly supporting its efficacy for this specific condition.