Evidence supporting the use of: Ligustilide
For the health condition: Chills

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Ligustilide is a phthalide compound found primarily in traditional Chinese medicinal herbs such as Angelica sinensis (Dong Quai) and Ligusticum chuanxiong (Chuanxiong). Its use to support or treat chills stems from traditional Chinese medicine (TCM) practices, where these herbs are often included in formulas intended to "invigorate blood" and "dispel wind-cold" to relieve symptoms such as chills and cold sensations. Historically, preparations containing ligustilide have been prescribed for conditions associated with poor circulation and cold extremities, which are sometimes described as "chills" in TCM terminology.

From a scientific standpoint, there is limited evidence directly linking ligustilide or its source herbs to the treatment of chills as understood in Western medicine (i.e., shivering due to fever or cold exposure). Most research on ligustilide focuses on its potential anti-inflammatory, neuroprotective, and vasodilatory properties, but not specifically on its effects on chills or thermoregulation. Therefore, the justification for using ligustilide for chills is primarily traditional, with weak or anecdotal evidence and no high-quality clinical studies directly supporting this use.

In summary, ligustilide's application for chills is rooted in traditional herbal practices rather than validated by modern scientific research.

More about Ligustilide
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