The use of Melia (commonly referring to Melia azedarach, also known as Chinaberry or Persian lilac) for the treatment or support of chills is primarily rooted in traditional medicine, particularly in certain Asian and Ayurvedic systems. Historical texts and some ethnomedicinal sources mention Melia as an ingredient in remedies aimed at alleviating symptoms associated with fever and chills, often as a part of polyherbal formulations for febrile illnesses. The rationale for its use is typically linked to its supposed antipyretic (fever-reducing) and anti-microbial properties. However, these traditional uses are not well-supported by modern scientific evidence.

There is a scarcity of rigorous clinical studies or pharmacological research directly evaluating the efficacy of Melia species for chills or related symptoms. The available scientific literature on Melia azedarach focuses more on its insecticidal, anti-parasitic, and general antimicrobial activities, rather than any specific antipyretic or chill-relieving effects. As such, the evidence is largely anecdotal and traditional, with little to no validation from controlled clinical trials.

In summary, while Melia has a history of traditional use for conditions involving chills, the strength of evidence is weak and not substantiated by modern clinical research.