Evidence supporting the use of: Brine
For the health condition: Cholera

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Brine, in the context of cholera treatment, refers to saline solutions used for rehydration. The mainstay of cholera management is prompt and effective rehydration to counter severe fluid and electrolyte loss due to profuse diarrhea. Scientific evidence strongly supports the use of Oral Rehydration Salts (ORS), which are essentially a balanced mixture of salts (including sodium chloride, or "brine") and glucose dissolved in clean water. ORS was developed and validated in the 20th century and has been credited with dramatically reducing mortality from cholera and other diarrheal diseases worldwide.

The mechanism is based on the sodium-glucose co-transport system in the intestines, which facilitates water absorption even during severe diarrheal illness. Numerous clinical trials and public health interventions have demonstrated that ORS reduces death rates and is safe, effective, and inexpensive. Traditional "brine" (saltwater without glucose or correct electrolyte balance) is not recommended as it can cause dangerous imbalances, but the scientifically formulated ORS is the standard of care.

In summary, the use of a salt-containing solution to treat cholera is scientifically validated, but it must be in the precise composition as found in ORS. Simply using brine (saltwater) is not equivalent or safe, but the principle of rehydration with electrolytes is the cornerstone of modern cholera therapy, supported by decades of research and clinical practice.

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